{"id":"W2555342181","doi":"10.1021/acs.biochem.6b00961","title":"Amphiphilicity Is a Key Determinant in the Membrane Interactions of Synthetic 14-mer Cationic Peptide Analogues","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regroupement Québécois sur les Matériaux de Pointe","funders":"Fonds de recherche du Québec – Nature et technologies; CermaVein; Agence Nationale de la Recherche; Natural Sciences and Engineering Research Council of Canada; Centre International de Recherche aux Frontières de la Chimie","keywords":"Membrane; Peptide; Chemistry; Cationic polymerization; Antimicrobial peptides; Biological membrane; Biophysics; Amphiphile; Context (archaeology); Stereochemistry; Combinatorial chemistry; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002040546,0.0001992536,0.0001890334,0.00007001383,0.00006769978,0.0001952066,0.0001328786,0.0002681222,0.000514738],"category_scores_gemma":[0.0002829123,0.00008488209,0.0001753852,0.00006990135,0.000164468,0.0002083232,0.0001393369,0.0003560235,0.0001761133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009141359,"about_ca_system_score_gemma":0.00007760801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007512567,"about_ca_topic_score_gemma":0.00007093879,"domain_scores_codex":[0.9998609,0.0000439476,0.00001432108,0.00002190714,0.00002967725,0.00002927435],"domain_scores_gemma":[0.9998561,0.00004279788,0.00004763497,0.00001020188,0.00001716585,0.0000259828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006034073,0.000009584273,0.00006695334,0.0000239882,0.000002708803,0.00004287961,0.000007601013,0.0000966471,0.998933,0.00005103894,0.000004434537,0.0007007912],"study_design_scores_gemma":[0.00001498599,0.0005904764,0.001633966,0.000006780169,0.0000119227,0.0002766979,0.00002160631,0.0007201069,0.9955315,0.00003432013,0.001151081,0.000006589891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977137,0.0005212051,0.001204081,0.00002223734,0.000006147323,0.00001339804,0.00002938898,0.00000678295,0.0004830064],"genre_scores_gemma":[0.9973336,0.0002920179,0.001856182,0.0000318334,0.000003372301,0.00001517963,0.00006967691,0.000005027269,0.0003932293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000514738,"threshold_uncertainty_score":0.001721978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212221724006042,"score_gpt":0.23639154590373,"score_spread":0.2242693286636696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}