{"id":"W2555379581","doi":"10.1182/blood.v126.23.4106.4106","title":"Age-Associated Acquired Mutations in Hematopoietic Cells Predominantly Affect Epigenetic Regulators TET2 and DNMT3A and Are Associated with Distinct Biological and Hematological Profiles","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"CEBPA; NPM1; Biology; Myeloid; Myelodysplastic syndromes; Population; Neuroblastoma RAS viral oncogene homolog; Myeloid leukemia; Genetics; Cancer research; KRAS; Oncology; Immunology; Mutation; Internal medicine; Medicine; Gene; Bone marrow; Chromosome; Karyotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001187018,0.0002169226,0.000263085,0.0004827128,0.0002011786,0.0002051862,0.0001177827,0.0001952948,0.003099119],"category_scores_gemma":[0.0003790178,0.0000993998,0.0001151343,0.0004049508,0.0001587543,0.0001322754,0.0001766095,0.0001316138,0.000359613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000980374,"about_ca_system_score_gemma":0.00009141838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008923006,"about_ca_topic_score_gemma":0.0008994002,"domain_scores_codex":[0.9998772,0.00001616497,0.00001091973,0.00004913976,0.00002314227,0.00002337528],"domain_scores_gemma":[0.9997994,0.00002883373,0.00009516897,0.00001285713,0.00002423255,0.0000396454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003382958,0.00004104479,0.9753901,0.00002689928,0.00004482501,0.0006964216,0.0000987879,0.00004215903,0.01800933,0.00003231672,0.0001270303,0.005152751],"study_design_scores_gemma":[0.000005414584,0.0001329345,0.9965259,0.000003554881,0.00002360511,0.002013253,0.00005570074,0.00004494924,0.0008177017,0.00002314018,0.0003518065,0.00000199846],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989956,0.0002537722,0.000131993,0.000008575421,0.000002490328,0.000005014976,0.0003079421,0.000003778718,0.0002908667],"genre_scores_gemma":[0.9990122,0.0001252374,0.00008675081,0.00002109762,0.000007375598,0.000005824538,0.000383161,0.000002288945,0.0003559543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003099119,"threshold_uncertainty_score":0.01036757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03021274417897262,"score_gpt":0.2745883247164481,"score_spread":0.2443755805374755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}