{"id":"W2555709927","doi":"10.1074/jbc.m116.762252","title":"Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; CHU Sainte-Justine Foundation","keywords":"C-C chemokine receptor type 6; Chemokine receptor; G protein-coupled receptor; Mutant; Chemistry; Cell biology; Receptor; Chemokine; CXCL11; Arrestin; XCL2; CCR3; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839499,0.0003670295,0.0002286244,0.0001656526,0.0002615489,0.0002729443,0.000349548,0.0004505609,0.004455979],"category_scores_gemma":[0.0001852252,0.0001336806,0.0003576579,0.0001659802,0.0003165839,0.0001285091,0.0002254198,0.0007418169,0.001263092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003891074,"about_ca_system_score_gemma":0.0003324496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002622918,"about_ca_topic_score_gemma":0.002764174,"domain_scores_codex":[0.9997509,0.00004936021,0.00002356173,0.00003434809,0.00007638049,0.00006533942],"domain_scores_gemma":[0.9998246,0.0000412988,0.00004047789,0.00002261801,0.00002550906,0.00004544749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001575744,0.00003807567,0.0002267281,0.00001943225,0.000008155733,0.0001255518,0.00001242694,0.00007570974,0.9982476,0.0002155875,0.0001039733,0.0007692151],"study_design_scores_gemma":[0.00004054348,0.0002831218,0.006230371,0.000009539228,0.00003771773,0.0009365261,0.00005502834,0.002313986,0.9854854,0.00007519258,0.004517266,0.00001540061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942203,0.0002491258,0.002776634,0.0001687565,0.00008590385,0.0000462361,0.0008154715,0.00008116353,0.001556395],"genre_scores_gemma":[0.9932173,0.0001554061,0.001669251,0.00007569543,0.00000825175,0.00003413982,0.0007461116,0.00004645004,0.004047299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004455979,"threshold_uncertainty_score":0.01490676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02314866808812919,"score_gpt":0.2762632983005194,"score_spread":0.2531146302123902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}