{"id":"W2555789082","doi":"10.1182/blood.v112.11.1605.1605","title":"A Novel Chromene-Based Pan-PI3 Kinase Inhibitor Displays Preclinical Activity in Leukemia and Myeloma.","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Kinase; Protein kinase B; Cell cycle; Cancer research; Cyclin; Leukemia; Cyclin-dependent kinase; PI3K/AKT/mTOR pathway; Biology; Chemistry; Phosphorylation; Biochemistry; Molecular biology; Cell biology; Cell; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001879651,0.0004368313,0.0003030185,0.0005183329,0.0001858337,0.0002008503,0.0002579619,0.0002877188,0.001882775],"category_scores_gemma":[0.00008303503,0.0001716206,0.0002337098,0.0003570045,0.0001657106,0.0001704476,0.0001440247,0.000474935,0.0002666507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004024945,"about_ca_system_score_gemma":0.000323592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002040486,"about_ca_topic_score_gemma":0.005026706,"domain_scores_codex":[0.9999396,0.00000727945,0.000003268039,0.00001322132,0.00001738284,0.00001935487],"domain_scores_gemma":[0.9999553,0.000007013085,0.00001089248,0.000004851853,0.000007342524,0.00001464137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000598686,0.000512933,0.0006059433,0.0001879959,0.00004010807,0.0001125384,0.00002932519,0.0009401422,0.9824928,0.0003277969,0.0005742482,0.01357748],"study_design_scores_gemma":[0.0005730234,0.01197733,0.01280653,0.00003671344,0.0001731067,0.0005224114,0.00002793072,0.002326564,0.9585357,0.0001479034,0.01285309,0.00001970663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750289,0.009644563,0.003688994,0.0002524608,0.00005475751,0.0003988932,0.002037433,0.0004402213,0.008453877],"genre_scores_gemma":[0.9784375,0.007991418,0.003976664,0.0002084353,0.00001620716,0.000158115,0.00278894,0.00002864487,0.00639404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002040486,"threshold_uncertainty_score":0.006298482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02255427564725975,"score_gpt":0.2680405126970433,"score_spread":0.2454862370497835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}