{"id":"W2555821255","doi":"10.1039/c6ob02246d","title":"Site-specific covalent capture of human O<sup>6</sup>-alkylguanine-DNA-alkyltransferase using single-stranded intrastrand cross-linked DNA","year":2016,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; DNA; Covalent bond; Stereochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001003377,0.0002216253,0.0001198909,0.00006629415,0.00006908065,0.0001636302,0.0001278067,0.0002000453,0.0006649129],"category_scores_gemma":[0.0001357258,0.0001133652,0.0001204108,0.00008361165,0.0001386989,0.0001204531,0.0001306602,0.0001942898,0.0002790845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001823266,"about_ca_system_score_gemma":0.0001350963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004680183,"about_ca_topic_score_gemma":0.0008626723,"domain_scores_codex":[0.9999307,0.000009051259,0.000003906018,0.00002540983,0.00001670759,0.00001416743],"domain_scores_gemma":[0.9999399,0.00001380502,0.0000162151,0.00001122025,0.000008423425,0.00001040234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001934855,0.000004782155,0.000106143,0.00001004907,0.000002399981,0.00001697003,0.000008366315,0.00006599169,0.9988683,0.00005400435,0.00001255347,0.0008311733],"study_design_scores_gemma":[9.415849e-7,0.00005273377,0.0003083319,4.023567e-7,0.000002061289,0.0000348809,0.00000349957,0.0002199222,0.9989769,0.000006031275,0.0003936538,7.037988e-7],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910135,0.0003137688,0.007161023,0.00002600787,0.00001483337,0.00002341006,0.00009943712,0.00009547856,0.001252609],"genre_scores_gemma":[0.9938058,0.0002029944,0.003368498,0.00001818647,0.000002988979,0.000009900364,0.0001728195,0.00001354991,0.00240526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006649129,"threshold_uncertainty_score":0.002224386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208389823938129,"score_gpt":0.2390786206228022,"score_spread":0.2269947223834209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}