{"id":"W2555862615","doi":"10.1182/blood.v118.21.3585.3585","title":"AML Cells Have Increased Mitochondrial Mass but Less Reserve in Their Respiratory Chain Complexes Leading to Heightened Sensitivity to Inhibition of Mitochondrial Protein Translation,","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Mitochondrial biogenesis; Mitochondrion; Citrate synthase; Mitochondrial respiratory chain; Respiratory chain; Oxidative phosphorylation; Antimycin A; Mitochondrial DNA; CD34; Haematopoiesis; Respiratory system; Biology; Cell biology; Chemistry; Molecular biology; Internal medicine; Biochemistry; Medicine; Stem cell; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043942,0.0003832342,0.0003558241,0.0002736455,0.0001387046,0.0005208701,0.0001356164,0.0002335314,0.001700502],"category_scores_gemma":[0.0001616215,0.0001311844,0.0002003647,0.0001863679,0.0002444035,0.000192181,0.0002380718,0.0005020629,0.0003709508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003130208,"about_ca_system_score_gemma":0.0001123461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005989501,"about_ca_topic_score_gemma":0.0008715084,"domain_scores_codex":[0.9997955,0.00001988578,0.00001937815,0.00004911467,0.00008474987,0.00003136176],"domain_scores_gemma":[0.9998852,0.00001936632,0.00004130249,0.0000133512,0.00001214164,0.00002857678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001294244,0.000018344,0.0009151249,0.00003273972,0.000005775742,0.00004806758,0.00001431989,0.00004920371,0.9971022,0.0000795408,0.00003199622,0.001573119],"study_design_scores_gemma":[0.00002955281,0.0005527291,0.03883478,0.00001033026,0.00002688633,0.0007509539,0.00009040234,0.000838313,0.9549577,0.0001356652,0.003766292,0.000006337038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944798,0.00195585,0.001756557,0.0001759082,0.00003033703,0.00001841315,0.0005756383,0.00006273695,0.000944865],"genre_scores_gemma":[0.9956642,0.0006849631,0.001226286,0.00006128132,0.00001004005,0.00002216501,0.0007764321,0.00001227341,0.001542465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700502,"threshold_uncertainty_score":0.005688727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03970025017729568,"score_gpt":0.2426472526239415,"score_spread":0.2029470024466458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}