{"id":"W2555913190","doi":"10.3389/fimmu.2016.00533","title":"Peptide IDR-1002 Inhibits NF-κB Nuclear Translocation by Inhibition of IκBα Degradation and Activates p38/ERK1/2–MSK1-Dependent CREB Phosphorylation in Macrophages Stimulated with Lipopolysaccharide","year":2016,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"CREB; Phosphorylation; Cell biology; CREB-binding protein; p38 mitogen-activated protein kinases; Inflammation; Signal transduction; Innate immune system; Transcription factor; NF-κB; Cyclic AMP Response Element-Binding Protein; Chemistry; Lipopolysaccharide; Coactivator; Biology; Immune system; Protein kinase A; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178497,0.0005370472,0.0003483413,0.0001742508,0.00009195477,0.0001805213,0.0001956437,0.0002679714,0.001586127],"category_scores_gemma":[0.0001098503,0.0001768013,0.000247435,0.0001281091,0.0002693769,0.000167348,0.0001316338,0.0007666624,0.0005040363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001527297,"about_ca_system_score_gemma":0.0001814261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002218113,"about_ca_topic_score_gemma":0.0003104944,"domain_scores_codex":[0.9999143,0.0000180332,0.000009613122,0.00001234797,0.0000207129,0.00002494962],"domain_scores_gemma":[0.9999444,0.00001248797,0.00001274931,0.00000697308,0.000004297121,0.00001907739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000546383,0.0001734312,0.00006157764,0.00007342258,0.000006228094,0.0000646539,0.000009674471,0.00007336393,0.9977581,0.00002714251,0.00004223552,0.001163881],"study_design_scores_gemma":[0.000331302,0.002927921,0.003708537,0.00001331352,0.00001851942,0.0005396652,0.00003615715,0.0009725305,0.9893113,0.00007144726,0.002058681,0.00001068939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952998,0.002123409,0.0009636426,0.00009829772,0.00004846144,0.00002975498,0.0001719523,0.00005921746,0.001205447],"genre_scores_gemma":[0.9934151,0.001993458,0.001197577,0.0001005788,0.00002810893,0.00008561926,0.0006775719,0.00001722826,0.002484754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586127,"threshold_uncertainty_score":0.005306184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003990597474235667,"score_gpt":0.1874771840602198,"score_spread":0.1834865865859842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}