{"id":"W2555967025","doi":"10.1182/blood.v114.22.2071.2071","title":"Improved Selectivity against Acute Myeloid Leukemia (AML) Blasts Over Normal Hematopoietic Progenitors for Cytarabine: Daunorubicin Delivered as CPX-351 Liposome Injection.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Celator Pharmaceuticals (Canada); BC Cancer Agency","funders":"","keywords":"Daunorubicin; Cytarabine; Medicine; Myeloid leukemia; Leukemia; Pharmacology; Chemotherapy; Progenitor cell; Internal medicine; Immunology; Oncology; Cancer research; Stem cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004382,0.0002699729,0.0001654681,0.0001948557,0.00007663542,0.0002997349,0.0001228373,0.0002768879,0.001253659],"category_scores_gemma":[0.00009474191,0.0001068822,0.0001168911,0.0001095485,0.0001426912,0.0002273644,0.0001215444,0.000412193,0.000337967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002377341,"about_ca_system_score_gemma":0.0001599893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004195451,"about_ca_topic_score_gemma":0.0003584539,"domain_scores_codex":[0.9999291,0.00001070612,0.00000469631,0.00002281171,0.00001606467,0.00001660934],"domain_scores_gemma":[0.9999682,0.000007664305,0.00001027439,0.000001936519,0.000004293119,0.000007645914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002172232,0.00004791835,0.00005097512,0.00004277248,0.000002092599,0.00001918046,0.00001173361,0.0000688498,0.9961362,0.0001192401,0.00007099713,0.003212702],"study_design_scores_gemma":[0.00004862024,0.0007828093,0.0009329324,0.000004758434,0.00001543598,0.0001523777,0.000006233441,0.001007273,0.9953781,0.0000165984,0.001651808,0.000002981585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897691,0.002546739,0.004896059,0.000168215,0.00004229765,0.0001521704,0.0002227732,0.0001796439,0.002023019],"genre_scores_gemma":[0.9929829,0.001077772,0.003626055,0.00005142626,0.000009409169,0.00003507311,0.0002240715,0.00001870038,0.001974694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253659,"threshold_uncertainty_score":0.004193902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004694487365373824,"score_gpt":0.2292535228954367,"score_spread":0.2245590355300629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}