{"id":"W2556024472","doi":"10.1371/journal.pbio.1002581","title":"SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis","year":2016,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Tumors and Oncological Cases","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Ontario Institute for Cancer Research","keywords":"Biology; SOX2; Cancer research; Stem cell; PI3K/AKT/mTOR pathway; Dysplasia; Cancer stem cell; Pathology; Immunology; Cell biology; Signal transduction; Medicine; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475572,0.0003329329,0.000303376,0.0003218057,0.0002343963,0.0004831757,0.0001912923,0.0002995284,0.001062646],"category_scores_gemma":[0.00009689645,0.0001955372,0.0003713828,0.0001878872,0.0002310775,0.0002672328,0.000337728,0.0004729401,0.0004428339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003639256,"about_ca_system_score_gemma":0.0002864799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009253364,"about_ca_topic_score_gemma":0.001259265,"domain_scores_codex":[0.9998117,0.00001975863,0.00001767325,0.00003266345,0.00005376682,0.00006447337],"domain_scores_gemma":[0.9999,0.000006346479,0.00001942988,0.00001618119,0.00001398722,0.00004415812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001974978,0.00003188076,0.003987135,0.0000312667,0.00001073819,0.0002782338,0.00002539457,0.00005852512,0.9935799,0.0001588195,0.00005713625,0.001583514],"study_design_scores_gemma":[0.00003791563,0.0003146043,0.1185222,0.000008033291,0.00003813743,0.001061238,0.0001273348,0.001895633,0.8748733,0.0002308743,0.002882054,0.000008717253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949617,0.00154779,0.001721623,0.00008542834,0.00001936462,0.00002188711,0.0002123751,0.0001106504,0.001319117],"genre_scores_gemma":[0.9975272,0.0003492992,0.0005657104,0.00002830664,0.000004984397,0.00002206504,0.0002795644,0.000007856107,0.001215058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001062646,"threshold_uncertainty_score":0.003554881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895385906695466,"score_gpt":0.247908303578176,"score_spread":0.2289544445112213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}