{"id":"W2556024472","doi":"10.1371/journal.pbio.1002581","title":"SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis","year":2016,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Tumors and Oncological Cases","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Ontario Institute for Cancer Research","keywords":"Biology; SOX2; Cancer research; Stem cell; PI3K/AKT/mTOR pathway; Dysplasia; Cancer stem cell; Pathology; Immunology; Cell biology; Signal transduction; Medicine; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702764,0.0002787317,0.0005692125,0.0001271222,0.0001239873,0.00001845527,0.00009993256,0.0001845636,0.0001019782],"category_scores_gemma":[0.0001108741,0.0001689063,0.0000446337,0.0001591051,0.0001679212,0.00004934936,0.0002469054,0.0001584414,0.000025853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008660919,"about_ca_system_score_gemma":0.00007340869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000588542,"about_ca_topic_score_gemma":0.00002985294,"domain_scores_codex":[0.9982163,0.0002021133,0.0003597261,0.0006069342,0.00009991231,0.0005150181],"domain_scores_gemma":[0.9987239,0.0003871107,0.00009373434,0.0002952688,0.0001150894,0.0003849072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006946208,0.0002020831,0.275653,0.0001765093,0.000004357515,0.0001947471,0.0002704031,1.512536e-7,0.7196751,0.000006036243,0.00009254648,0.00303048],"study_design_scores_gemma":[0.004130234,0.00445295,0.472566,0.00004461019,0.0001314709,0.0001207305,0.0002567608,0.00002852064,0.5170259,0.00002578789,0.0007803491,0.0004366363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966764,0.001414113,0.00001852703,0.0006871166,0.0000740961,0.0006650127,0.0001918046,0.00008793885,0.0001849182],"genre_scores_gemma":[0.9981835,0.0001082922,0.000141307,0.0006527459,0.0001017908,0.00007142356,0.000007427103,0.0000347232,0.0006987617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2026491,"threshold_uncertainty_score":0.6887801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895385906695466,"score_gpt":0.247908303578176,"score_spread":0.2289544445112213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}