{"id":"W2556069984","doi":"10.1021/acsinfecdis.6b00177","title":"Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate","year":2016,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Helicase; Nucleic acid; Substrate (aquarium); Chemistry; Virology; Biology; Biochemistry; RNA; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886675,0.000182039,0.00022909,0.0001665537,0.0001875138,0.0004126661,0.0002393402,0.0001918475,0.001463366],"category_scores_gemma":[0.0005498483,0.0001729008,0.0001282908,0.0001378577,0.0002912295,0.00030184,0.0001914992,0.000435483,0.000239379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000369532,"about_ca_system_score_gemma":0.0001633217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310666,"about_ca_topic_score_gemma":0.001385344,"domain_scores_codex":[0.9998779,0.00001381538,0.000004440264,0.00002954878,0.00003844086,0.00003581517],"domain_scores_gemma":[0.9997742,0.00009877757,0.00003330726,0.00002037131,0.00003485654,0.00003869631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000213747,0.00003692832,0.001342273,0.00003087298,0.00001111706,0.0001186112,0.0001505046,0.000707089,0.993874,0.0004079458,0.00007270171,0.003034276],"study_design_scores_gemma":[0.00001424933,0.000159911,0.02400595,0.00001046159,0.0000147883,0.0001519151,0.0001489716,0.02329921,0.9512531,0.0002359971,0.0006760028,0.00002947617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978548,0.0001005083,0.001137443,0.00002104013,0.000003806568,0.000005950089,0.00004638773,0.00003061817,0.0007995358],"genre_scores_gemma":[0.9991453,0.00005783226,0.0003835528,0.00001038573,0.000001513948,0.000008113124,0.000046604,0.00001071515,0.0003358763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001463366,"threshold_uncertainty_score":0.004895389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006139923098327961,"score_gpt":0.2312679660942795,"score_spread":0.2251280429959516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}