{"id":"W2556069984","doi":"10.1021/acsinfecdis.6b00177","title":"Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate","year":2016,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Helicase; Nucleic acid; Substrate (aquarium); Chemistry; Virology; Biology; Biochemistry; RNA; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004463335,0.0001295574,0.0001007477,0.00004281394,0.0001056248,0.0000138657,0.0001663191,0.00007519106,0.00003869279],"category_scores_gemma":[0.0001495239,0.00007379381,0.0001044922,0.0000707143,0.0001480718,0.000005981934,0.00009030214,0.00004867349,0.00002229628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002161247,"about_ca_system_score_gemma":0.00004224132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008712296,"about_ca_topic_score_gemma":0.00003171137,"domain_scores_codex":[0.9993694,0.00004656467,0.0001273612,0.0002094834,0.00008452555,0.0001627074],"domain_scores_gemma":[0.9993953,0.00004310668,0.00007941854,0.0003682239,0.00004976493,0.00006415783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008544149,0.00008065085,0.009957951,0.0000174459,0.00009105883,0.000004638131,0.00001546149,0.00002671942,0.9823313,0.001837704,0.0002983256,0.00525327],"study_design_scores_gemma":[0.001552506,0.001076099,0.01057604,0.0001939952,0.0001706661,0.00003498409,0.0002027536,0.0002447672,0.9761845,0.007406962,0.001764138,0.0005926004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975139,0.0001731584,0.0007030399,0.0001798352,0.0000909787,0.0001429577,0.000175442,0.00002527826,0.0009953327],"genre_scores_gemma":[0.9993462,0.0002165299,0.00001429987,0.0001998036,0.00003892476,0.00002036069,0.000028682,0.00001674012,0.000118476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006146847,"threshold_uncertainty_score":0.3009224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006139923098327961,"score_gpt":0.2312679660942795,"score_spread":0.2251280429959516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}