{"id":"W2556091347","doi":"10.1182/blood.v126.23.1675.1675","title":"Prognostic Impact of TS, MTHFR and XRCC1 Genetic Variants in 113 Patients with Myelodysplastic Syndromes","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Methylenetetrahydrofolate reductase; XRCC1; Myelodysplastic syndromes; Single-nucleotide polymorphism; Genotype; Internal medicine; International Prognostic Scoring System; XRCC3; Biology; Oncology; Hazard ratio; Genetics; Proportional hazards model; Gastroenterology; Medicine; Gene; Bone marrow; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005111856,0.0004116713,0.000555283,0.001092925,0.0006172024,0.0004627546,0.0003003445,0.0006211799,0.001171098],"category_scores_gemma":[0.001681571,0.0003215193,0.0003924222,0.001073346,0.000419879,0.0001948182,0.0004032431,0.000486979,0.0002217083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002921974,"about_ca_system_score_gemma":0.0002195653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001663463,"about_ca_topic_score_gemma":0.001518875,"domain_scores_codex":[0.9995989,0.00009525184,0.00005579077,0.0001043788,0.00008370444,0.00006204377],"domain_scores_gemma":[0.9992579,0.0002043905,0.0002779742,0.00005531988,0.00007305623,0.0001313795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002584308,0.00001513012,0.9978117,0.000006794837,0.00002854795,0.0002171336,0.00005033117,0.00005666884,0.0007047918,0.000007625105,0.00002918712,0.0008136401],"study_design_scores_gemma":[0.00002194175,0.000239456,0.9977729,0.000005830597,0.00007726825,0.001172047,0.00009384942,0.0001854526,0.0002575174,0.00002434075,0.0001448191,0.000004490429],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996215,0.000139734,0.00004343588,0.000007826713,0.00000191852,0.000002803414,0.0001063327,0.000001668614,0.00007477549],"genre_scores_gemma":[0.9995742,0.00005177109,0.00005213565,0.000005638813,0.000004333327,0.000004918279,0.0002632764,0.000001337462,0.00004242744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001663463,"threshold_uncertainty_score":0.003917754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669592014258893,"score_gpt":0.2709063805026464,"score_spread":0.2542104603600575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}