{"id":"W2556182164","doi":"10.1182/blood.v124.21.2226.2226","title":"Ibrutinib Sensitizes AML Cells to ROS Inducers Via a BTK-Independent Mechanism","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Mount Sinai Hospital; University of Toronto; University Health Network","funders":"","keywords":"Ibrutinib; Bruton's tyrosine kinase; Cancer research; Tyrosine kinase; Cytotoxicity; Pharmacology; Leukemia; Cell culture; Immunology; Chronic lymphocytic leukemia; Medicine; Chemistry; Biology; Signal transduction; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109617,0.0004286003,0.0004300624,0.0002605148,0.0001466946,0.0002896114,0.0001946505,0.0001795905,0.002333059],"category_scores_gemma":[0.00008115857,0.0001253456,0.0002382247,0.0002710073,0.0001397182,0.0001178947,0.0002033785,0.0005196785,0.0005503349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003082264,"about_ca_system_score_gemma":0.0001551277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007646953,"about_ca_topic_score_gemma":0.001173118,"domain_scores_codex":[0.9998713,0.00001845023,0.00001281041,0.00002090356,0.00004339584,0.00003325311],"domain_scores_gemma":[0.9999487,0.000009387266,0.00001070731,0.000009338673,0.000008570499,0.00001320242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001303384,0.00003926331,0.000168166,0.00003561112,0.0000057766,0.00002891864,0.00001011582,0.0001129863,0.9976946,0.00002866003,0.0000778162,0.001667731],"study_design_scores_gemma":[0.00003758961,0.0006497402,0.00372205,0.000005729662,0.00001356109,0.0002148334,0.0000192288,0.000515251,0.9915944,0.00002449315,0.003199686,0.000003407706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895365,0.002351474,0.002610857,0.0001550267,0.00004093704,0.0000885924,0.0009998162,0.0002028076,0.004013931],"genre_scores_gemma":[0.9916683,0.001365548,0.002106781,0.00008257804,0.0000154267,0.00006101419,0.001553865,0.00002175035,0.003124716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002333059,"threshold_uncertainty_score":0.007804811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270738736565406,"score_gpt":0.2623440579190436,"score_spread":0.2496366705533895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}