{"id":"W2556367247","doi":"10.1016/j.chom.2016.10.008","title":"Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth","year":2016,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Burroughs Wellcome Fund; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Francisella; Francisella tularensis; Effector; Biology; Virulence; Tularemia; Pathogenicity island; Type VI secretion system; Microbiology; Secretion; Proteome; Organism; Pathogen; Genetics; Gene; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001811797,0.0004180394,0.0002207206,0.000216486,0.0002174853,0.0005673324,0.0001362696,0.0003273471,0.001538519],"category_scores_gemma":[0.000326825,0.0001322605,0.0002368935,0.00009829642,0.000250402,0.0003427441,0.0006220826,0.0006867449,0.0006721293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002676081,"about_ca_system_score_gemma":0.0002468122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005168863,"about_ca_topic_score_gemma":0.001073646,"domain_scores_codex":[0.9997918,0.00002762766,0.00001052021,0.00002093384,0.00004323406,0.0001059543],"domain_scores_gemma":[0.9997358,0.00008090486,0.00003251878,0.00003379345,0.00003676731,0.00008015316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002306977,0.00003818715,0.0002150687,0.00001203069,0.00000134497,0.0000370065,0.00002053086,0.00002419973,0.9982435,0.0001285242,0.00003281175,0.001016079],"study_design_scores_gemma":[0.00001777606,0.000200555,0.003642357,0.000006067208,0.000007028406,0.0001054788,0.00008240523,0.0006464894,0.9943972,0.00005207607,0.0008376969,0.000004970491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958853,0.0004622164,0.001408269,0.00005350401,0.00002711793,0.000009603413,0.00004605249,0.00005171178,0.002056186],"genre_scores_gemma":[0.9965029,0.0001178048,0.0008966224,0.00002150071,0.000009259077,0.000007732413,0.0001707328,0.00002674021,0.002246747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001538519,"threshold_uncertainty_score":0.005146861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003220169790878209,"score_gpt":0.1917726593473187,"score_spread":0.1885524895564404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}