{"id":"W2556367247","doi":"10.1016/j.chom.2016.10.008","title":"Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth","year":2016,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Burroughs Wellcome Fund; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute","keywords":"Francisella; Francisella tularensis; Effector; Biology; Virulence; Tularemia; Pathogenicity island; Type VI secretion system; Microbiology; Secretion; Proteome; Organism; Pathogen; Genetics; Gene; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003236325,0.0001958598,0.0002146638,0.00002644273,0.00009552325,0.0000229052,0.000284387,0.0002000409,0.0000512115],"category_scores_gemma":[0.0001289433,0.0001108108,0.0001098156,0.0001065911,0.0002867853,0.000004317631,0.0002527591,0.000112001,0.00000954984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001268036,"about_ca_system_score_gemma":0.00007743957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005116224,"about_ca_topic_score_gemma":0.00007263316,"domain_scores_codex":[0.998782,0.0001422074,0.0002521913,0.0003837333,0.0001316939,0.0003082078],"domain_scores_gemma":[0.999199,0.00003213744,0.0001257897,0.0004076978,0.0001308875,0.0001045358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001597767,0.00003745646,0.004042643,0.00008514529,0.0000234925,0.000002752697,0.0001555151,2.070691e-7,0.9942893,0.000007641251,0.0002625013,0.0009335985],"study_design_scores_gemma":[0.001125208,0.0002094091,0.00538587,0.00004346615,0.00001800724,0.000009660905,0.00000963966,0.00000640898,0.9910834,0.00004201073,0.001901511,0.0001653497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973919,0.0007558544,0.0005869221,0.00006957436,0.0002087988,0.000416145,0.0001724577,0.000007098714,0.0003912272],"genre_scores_gemma":[0.9986714,0.0002605128,0.0001352082,0.00006710036,0.0001070211,0.000009708418,0.00001382863,0.00002815628,0.0007071002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003205811,"threshold_uncertainty_score":0.4518732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003220169790878209,"score_gpt":0.1917726593473187,"score_spread":0.1885524895564404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}