{"id":"W2556496813","doi":"10.1021/acs.molpharmaceut.6b00788","title":"Effect of Extent of Supersaturation on the Evolution of Kinetic Solubility Profiles","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Supersaturation; Solubility; Dissolution; Chemistry; Precipitation; Crystallization; Nucleation; Solubility equilibrium; Thermodynamics; Bioavailability; Chemical engineering; Chromatography; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004455621,0.0003332855,0.0003166234,0.0002058075,0.0001200601,0.000320846,0.0001837294,0.0002160308,0.0008910028],"category_scores_gemma":[0.001219453,0.0001816611,0.0002725267,0.0002426656,0.0002536676,0.0004077575,0.0002355696,0.0005703377,0.0001731374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003576146,"about_ca_system_score_gemma":0.0003672162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171514,"about_ca_topic_score_gemma":0.001382927,"domain_scores_codex":[0.9996558,0.00007189024,0.00004273194,0.00005346288,0.0001309429,0.00004502283],"domain_scores_gemma":[0.9987716,0.0006915111,0.0002451708,0.00007016146,0.0001775932,0.00004393809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004317556,0.00004726124,0.001136447,0.00007587727,0.00001324964,0.00005123104,0.00006279119,0.001356154,0.9930205,0.00008029278,0.00002536619,0.003699121],"study_design_scores_gemma":[0.000005612856,0.0004071571,0.002766639,0.00000336829,0.00001308703,0.0000245108,0.00001778642,0.002093356,0.9942957,0.00002252741,0.0003451506,0.000005316365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939426,0.001018693,0.003323701,0.00006001106,0.00001555848,0.00004533836,0.0002320519,0.00005109974,0.001310929],"genre_scores_gemma":[0.9958066,0.0009802188,0.002515867,0.0000282168,0.00000891243,0.00003008688,0.0001802017,0.00002144384,0.0004284023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171514,"threshold_uncertainty_score":0.002980709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05297954157970207,"score_gpt":0.3876120193671523,"score_spread":0.3346324777874502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}