{"id":"W2556519767","doi":"10.1371/journal.pone.0166187","title":"Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency; University of Calgary","funders":"Alberta Prion Research Institute; National Institutes of Health; Canada Research Chairs","keywords":"Chronic wasting disease; Feces; Biology; Genotype; Transmission (telecommunications); Disease; Virology; Prion protein; Incubation period; Inoculation; Incubation; Microbiology; Immunology; Medicine; Genetics; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000558448,0.0003508586,0.0002785035,0.0002704392,0.0001378037,0.0004730183,0.0002920406,0.0003961259,0.0004069702],"category_scores_gemma":[0.0008671824,0.00014931,0.0002228649,0.0001490183,0.0003748061,0.0002200944,0.0001932955,0.0004879073,0.0002497059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002265013,"about_ca_system_score_gemma":0.0001204159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009722126,"about_ca_topic_score_gemma":0.001428652,"domain_scores_codex":[0.9993999,0.0001215544,0.00007148697,0.0001852768,0.0001433115,0.00007840489],"domain_scores_gemma":[0.9992456,0.0002603434,0.0002356526,0.00008396606,0.0001236869,0.00005081296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007981107,0.00003076618,0.001794145,0.00002599144,0.000003076807,0.00005019202,0.00004470263,0.00003410069,0.9968103,0.00001070549,0.00001052969,0.001105668],"study_design_scores_gemma":[0.000009454516,0.0007513486,0.04140241,0.00001769754,0.00003646214,0.0004670387,0.0001381055,0.002309327,0.9541871,0.00003115253,0.0006297231,0.00002009104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903623,0.0003624574,0.008279352,0.00003902087,0.00002155126,0.000075924,0.0002964844,0.00009104617,0.0004719371],"genre_scores_gemma":[0.9752204,0.0004231673,0.02166713,0.0001080155,0.000009122892,0.00008138367,0.0007756141,0.00003473688,0.001680517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009722126,"threshold_uncertainty_score":0.00295341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216900809542434,"score_gpt":0.2117804714584834,"score_spread":0.199611463363059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}