{"id":"W2556519767","doi":"10.1371/journal.pone.0166187","title":"Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency; University of Calgary","funders":"Alberta Prion Research Institute; National Institutes of Health; Canada Research Chairs","keywords":"Chronic wasting disease; Feces; Biology; Genotype; Transmission (telecommunications); Disease; Virology; Prion protein; Incubation period; Inoculation; Incubation; Microbiology; Immunology; Medicine; Genetics; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008120394,0.000083949,0.0001092863,0.00003895352,0.00004901561,0.00000885209,0.00006258064,0.00006645492,0.0000137196],"category_scores_gemma":[0.0001735928,0.00007216466,0.00003045999,0.00005237573,0.00003374117,0.000009364119,0.00007805148,0.00003500797,0.000003611757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002779097,"about_ca_system_score_gemma":0.00006233744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003950522,"about_ca_topic_score_gemma":0.00001371741,"domain_scores_codex":[0.9993734,0.00004009895,0.0001348772,0.0002134214,0.00009625046,0.0001419372],"domain_scores_gemma":[0.9996096,0.00003146656,0.00009332526,0.0001371292,0.00003939502,0.00008906523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000849773,0.0001154785,0.01653738,0.0001535477,0.00003405456,0.000001262295,0.00001889006,3.792861e-7,0.978555,0.000001052341,0.000003951845,0.00449403],"study_design_scores_gemma":[0.000629003,0.0002290798,0.02345425,0.0007233177,0.00003548742,2.134959e-7,0.000009561558,0.0001033315,0.9746863,0.00001279545,0.000009401759,0.0001072115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979243,0.001646744,0.0001030275,0.00006183239,0.00001009533,0.0002024683,0.00002260777,0.000007797143,0.00002107133],"genre_scores_gemma":[0.9961894,0.003602151,0.00006525152,0.000009799974,0.00005525188,0.00001894267,0.00001166548,0.0000114364,0.00003614182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006916871,"threshold_uncertainty_score":0.2942789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216900809542434,"score_gpt":0.2117804714584834,"score_spread":0.199611463363059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}