{"id":"W2556545060","doi":"10.1002/slct.201601536","title":"Total Synthesis of the Natural Product (+)‐ <i>trans</i> ‐Dihydronarciclasine via an Asymmetric Organocatalytic [3+3]‐Cycloaddition and discovery of its potent anti‐Zika Virus (ZIKV) Activity","year":2016,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Natural product; Cinnamaldehyde; Cycloaddition; Zika virus; Total synthesis; Enantioselective synthesis; Cascade; Combinatorial chemistry; Stereochemistry; Chemistry; Virology; Virus; Biology; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490385,0.0003519803,0.0005414351,0.00004072746,0.00009375998,0.00002831515,0.000413519,0.0001627267,0.0001560379],"category_scores_gemma":[0.0007204307,0.0002177813,0.0002212166,0.0004522768,0.0003145831,0.0003463341,0.0001266198,0.0002349881,0.000001857307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001291319,"about_ca_system_score_gemma":0.00009410227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003900675,"about_ca_topic_score_gemma":0.000003669338,"domain_scores_codex":[0.9980744,0.00003073991,0.0004208495,0.0006247899,0.0004555509,0.0003936732],"domain_scores_gemma":[0.9983938,0.0003547607,0.0003353282,0.0006763951,0.0001247179,0.0001149382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001101513,0.0003642361,0.0009790113,0.0005611547,0.00008462933,0.000001879995,0.00001792531,8.000976e-7,0.9598747,0.000002520719,0.00005292581,0.03795008],"study_design_scores_gemma":[0.0003917574,0.00001917811,0.004242862,0.0003216549,0.000135493,0.0000667957,0.000009274002,0.0000551287,0.9943436,0.00003199655,0.00007092419,0.0003113007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977556,0.000601902,0.00002921574,0.0002896224,0.00004976425,0.0001120288,0.0003319132,0.00004344917,0.0007864783],"genre_scores_gemma":[0.9990488,0.0001760491,0.00002239506,0.000008529949,0.0001843933,0.00001994917,0.00002036568,0.00004315515,0.0004763623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03763878,"threshold_uncertainty_score":0.8880864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005124008806065579,"score_gpt":0.1943946877035949,"score_spread":0.1892706788975294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}