{"id":"W2556763113","doi":"10.1182/blood.v110.11.257.257","title":"Identification of Vacuolar H+- ATPase as a Target for Myeloma Therapeutics.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Bafilomycin; Viability assay; Cell culture; MTT assay; Gene knockdown; Small hairpin RNA; Apoptosis; Cell growth; Molecular biology; Multiple myeloma; Cytotoxic T cell; Biology; Cancer research; Chemistry; In vitro; Immunology; Biochemistry; Autophagy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096925,0.0003079071,0.0004400719,0.0003045831,0.0001726825,0.000379125,0.0002057807,0.0003614418,0.001114577],"category_scores_gemma":[0.0001039682,0.0001558323,0.0002988082,0.0002637865,0.000134112,0.0001317273,0.0001450045,0.0004467123,0.0004588862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000485659,"about_ca_system_score_gemma":0.0002531156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006814607,"about_ca_topic_score_gemma":0.001793593,"domain_scores_codex":[0.9999136,0.0000100091,0.000007046513,0.00001873507,0.00003947629,0.00001124353],"domain_scores_gemma":[0.9999083,0.00001534541,0.0000201849,0.000009109821,0.00002868672,0.00001836286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004801068,0.00001818192,0.0004546373,0.00005972747,0.000009066996,0.00005086282,0.000005515883,0.00006546786,0.9955952,0.0000534646,0.0001797144,0.003460247],"study_design_scores_gemma":[0.00002137871,0.0003903281,0.005261721,0.00001237026,0.00004780643,0.000637265,0.00001823251,0.0008518209,0.9857927,0.00005211961,0.006909894,0.000004287011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620354,0.01626692,0.01313905,0.0008139136,0.0001158681,0.0002665097,0.002908355,0.0004434631,0.004010497],"genre_scores_gemma":[0.9756685,0.005159182,0.01041883,0.0002344968,0.00002538638,0.00007455226,0.003702111,0.00004172434,0.004675178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114577,"threshold_uncertainty_score":0.003728628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521178933561513,"score_gpt":0.3180286673935708,"score_spread":0.3028168780579557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}