{"id":"W2556883203","doi":"10.21037/sci.2016.10.12","title":"E-cadherin adhesion-mediated Wnt activation for mesoderm specification in human embryonic stem cells needs a soft mattress","year":2016,"lang":"en","type":"letter","venue":"Stem Cell Investigation","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Mesoderm; Cell biology; Cadherin; Wnt signaling pathway; Embryonic stem cell; Stem cell; Biology; Brachyury; Anatomy; Cellular differentiation; Cell; Genetics; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006474575,0.0002271466,0.0003140787,0.0001431641,0.0006014073,0.0009302146,0.0002989903,0.004040128,0.003186657],"category_scores_gemma":[0.001989942,0.0001628921,0.0003926224,0.0001684191,0.0008449535,0.0004827556,0.0003442706,0.003911467,0.002591237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009489987,"about_ca_system_score_gemma":0.0004052961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004593464,"about_ca_topic_score_gemma":0.0008358641,"domain_scores_codex":[0.9995906,0.0001054102,0.0000548866,0.00003704277,0.0001451785,0.00006693879],"domain_scores_gemma":[0.9992343,0.0004135707,0.00007712136,0.00007060928,0.0001162511,0.000088208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001833211,0.0004069983,0.004734203,0.0006341556,0.00007057936,0.04350147,0.0005585137,0.0006739207,0.141376,0.03491255,0.6000044,0.1712939],"study_design_scores_gemma":[0.0003758501,0.0004517161,0.004470749,0.0001170053,0.00005107348,0.01725861,0.0003629782,0.002622684,0.05749407,0.01556468,0.9011788,0.00005168829],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.04840986,0.01288898,0.003680593,0.8807849,0.02235743,0.0001001987,0.0003663808,0.0002741289,0.03113748],"genre_scores_gemma":[0.4841999,0.02892504,0.007048225,0.3448147,0.02963111,0.000423924,0.0005551614,0.000136666,0.1042652],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004040128,"threshold_uncertainty_score":0.01066041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0272964060881773,"score_gpt":0.2327710776819941,"score_spread":0.2054746715938168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}