{"id":"W2557042778","doi":"10.1182/blood.v116.21.518.518","title":"Trough Level of First Dose of Busulfan (Cmin1) Is a Stronger Predictor of Graft Rejection Than Steady State Concentration (Css1) In Patients with Beta Thalassemia Major Undergoing Allogeneic Hematopoietic Stem Cell Transplantation","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Busulfan; Medicine; Dosing; Gastroenterology; Transplantation; Internal medicine; Cohort; Thalassemia; Hematopoietic stem cell transplantation; Median follow-up; Surgery; Oncology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002446122,0.0002071682,0.00032503,0.0003853769,0.0002314588,0.0004020996,0.0001480968,0.0002351049,0.001065246],"category_scores_gemma":[0.001026728,0.0001904851,0.0002595546,0.0003579123,0.0001918686,0.0002246195,0.0001782251,0.0004527481,0.0001600794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002170701,"about_ca_system_score_gemma":0.0001638277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008131411,"about_ca_topic_score_gemma":0.0008668483,"domain_scores_codex":[0.9998505,0.0000315841,0.00002293422,0.00003026622,0.00003333459,0.00003141084],"domain_scores_gemma":[0.999245,0.0001847822,0.0003507143,0.00003645935,0.00003640373,0.0001466109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002725799,0.00002033418,0.997712,0.000003846054,0.00001656664,0.0001720242,0.00003130029,0.00005233884,0.0008550896,0.000007061742,0.00002566457,0.0008311435],"study_design_scores_gemma":[0.00001076839,0.000376465,0.9977169,0.000002306952,0.00002188913,0.001116256,0.0000515308,0.0002916016,0.0002922795,0.00001271989,0.000104877,0.000002438807],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997776,0.00007251994,0.00002170985,0.000007302027,0.000001450532,0.000001434235,0.0000301489,9.756708e-7,0.00008691412],"genre_scores_gemma":[0.9998109,0.00003132676,0.00001803684,0.000006171459,0.000003923693,0.000001515667,0.00007817516,5.623554e-7,0.00004946383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065246,"threshold_uncertainty_score":0.003563643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030549408357328,"score_gpt":0.2110318441201544,"score_spread":0.2007263500365811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}