{"id":"W2557141539","doi":"10.1038/cdd.2016.133","title":"Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity","year":2016,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":855,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"FOXO3; Gene silencing; Apoptosis; microRNA; Puma; Competing endogenous RNA; Downregulation and upregulation; Ectopic expression; Mdm2; Cell biology; Small interfering RNA; Biology; Messenger RNA; Endogeny; Cancer research; Chemistry; Molecular biology; RNA; Gene; Long non-coding RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002466659,0.0003189688,0.0001864573,0.0002418511,0.0001991505,0.0002459037,0.0001368833,0.0002405034,0.003151361],"category_scores_gemma":[0.0001798273,0.0001168924,0.0003735883,0.0001456337,0.000310049,0.0001939382,0.0002654595,0.0007023508,0.0002832918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003818104,"about_ca_system_score_gemma":0.0003446614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004964834,"about_ca_topic_score_gemma":0.0008394176,"domain_scores_codex":[0.9998665,0.00002037611,0.000008365369,0.00003112282,0.00002667957,0.00004694313],"domain_scores_gemma":[0.9998504,0.00003123703,0.00004331575,0.00002217481,0.00001489384,0.00003797262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005617877,0.00008041944,0.0002432439,0.00005169911,0.00001020514,0.00003636456,0.00001757357,0.0001162128,0.9952008,0.0004937826,0.0001177303,0.003070205],"study_design_scores_gemma":[0.00008851825,0.0009666063,0.002183292,0.00001060831,0.00002871928,0.0000892897,0.0000292361,0.0007075161,0.9921028,0.0001713181,0.003615444,0.000006727562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878022,0.001497196,0.005570293,0.000332309,0.0001200873,0.00005295155,0.0003574054,0.0002304581,0.004037162],"genre_scores_gemma":[0.9937075,0.0004627538,0.002248348,0.00008913151,0.00002130254,0.00003199555,0.0003470048,0.0000255063,0.003066536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003151361,"threshold_uncertainty_score":0.01054233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194232775641283,"score_gpt":0.2313189650471162,"score_spread":0.2193766372907034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}