{"id":"W2557178154","doi":"10.1097/tp.0000000000001559","title":"Effect of Ex Vivo–Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques","year":2016,"lang":"en","type":"article","venue":"Transplantation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"FOXP3; Immunosuppression; Immunology; Transplantation Chimera; Immune tolerance; Medicine; T cell; IL-2 receptor; Regulatory T cell; Haematopoiesis; Transplantation; Immune system; Stem cell; Biology; Internal medicine; Hematopoietic cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003153794,0.0002282558,0.0003873431,0.0001043632,0.00008679679,0.000005932543,0.0001327199,0.0003056518,0.0002098963],"category_scores_gemma":[0.00001804338,0.0001618726,0.00007296683,0.00008639068,0.0003661454,0.00008658769,0.00001307448,0.0001698222,0.00005476179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002860126,"about_ca_system_score_gemma":0.00002783024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009413167,"about_ca_topic_score_gemma":0.00003240149,"domain_scores_codex":[0.9985009,0.000370025,0.0003662576,0.0003584758,0.0000465788,0.0003577367],"domain_scores_gemma":[0.9993091,0.0002731431,0.000128195,0.0002228245,0.00002086445,0.00004591452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002101818,0.00005243103,0.005238933,0.0001740763,0.00006061691,0.00001542345,0.002329938,0.000003922446,0.9863205,0.00006133222,0.0001452327,0.003495799],"study_design_scores_gemma":[0.005378601,0.0008340721,0.004467414,0.000351285,0.00004867425,0.00006797496,0.00005677604,0.000001496921,0.9878486,0.00004189379,0.0007113256,0.0001919194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978641,0.0006672672,0.0001074955,0.0001484256,0.0005265297,0.0003367201,0.0001129344,0.0000480309,0.0001884915],"genre_scores_gemma":[0.9980657,0.001104938,0.0000198194,0.0001219712,0.00001171405,0.00003159112,0.00004753988,0.00001785844,0.000578942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00330388,"threshold_uncertainty_score":0.6600971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004340229349282832,"score_gpt":0.2295705976398473,"score_spread":0.2252303682905645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}