{"id":"W2557209790","doi":"10.1007/s00726-016-2364-3","title":"Efficient oxidation of N-protected tryptophan and tryptophanyl-dipeptides by in situ generated dimethyldioxirane provides hexahydropyrroloindoline-containing synthons suitable for peptide synthesis and subsequent tryptathionylation","year":2016,"lang":"en","type":"article","venue":"Amino Acids","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Trifluoroacetic acid; Peptide synthesis; Peptide; Synthon; Monomer; Dimethyldioxirane; Organic chemistry; Tryptophan; Combinatorial chemistry; Cysteine; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006355178,0.000272433,0.0003820065,0.0001225643,0.00009417287,0.000022227,0.0001213784,0.0002438893,0.000006621655],"category_scores_gemma":[0.001076336,0.000218384,0.00006760514,0.0001603151,0.0001556647,0.00001584321,0.0000940207,0.00007999859,9.288128e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000484201,"about_ca_system_score_gemma":0.00006540757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006488053,"about_ca_topic_score_gemma":0.00009047051,"domain_scores_codex":[0.9981494,0.0002119084,0.000524329,0.0005848931,0.0001594369,0.0003700312],"domain_scores_gemma":[0.9989876,0.000258196,0.0002460514,0.0002664702,0.0001449488,0.000096778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003867112,0.0001230837,0.005005756,0.00006339698,0.00004936599,2.752814e-7,0.000149371,0.00004967007,0.9871365,0.00003983288,0.00004870117,0.00694734],"study_design_scores_gemma":[0.002110435,0.000530328,0.003598885,0.0001093847,0.00004602681,0.000008264638,0.0001700479,0.0007117565,0.9921976,0.00002524049,0.0002216991,0.0002703044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864724,0.0009672609,0.0112447,0.0001789464,0.00005991671,0.0009684319,0.0000540864,0.00002378122,0.00003048595],"genre_scores_gemma":[0.9946975,0.0002423988,0.004390878,0.00002811593,0.0000775869,0.0002778102,0.00007052111,0.00004032004,0.000174941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008225033,"threshold_uncertainty_score":0.8905442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041006894130088,"score_gpt":0.2446579537660772,"score_spread":0.2342478848247763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}