{"id":"W2557209790","doi":"10.1007/s00726-016-2364-3","title":"Efficient oxidation of N-protected tryptophan and tryptophanyl-dipeptides by in situ generated dimethyldioxirane provides hexahydropyrroloindoline-containing synthons suitable for peptide synthesis and subsequent tryptathionylation","year":2016,"lang":"en","type":"article","venue":"Amino Acids","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Trifluoroacetic acid; Peptide synthesis; Peptide; Synthon; Monomer; Dimethyldioxirane; Organic chemistry; Tryptophan; Combinatorial chemistry; Cysteine; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002977228,0.000520035,0.0001935661,0.000137514,0.000108883,0.0001356299,0.0003552438,0.0002933558,0.001275387],"category_scores_gemma":[0.0001828287,0.0002075274,0.0001699468,0.0001024146,0.0001963634,0.0002421696,0.0002303145,0.0003945525,0.0004196533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002563169,"about_ca_system_score_gemma":0.0001669529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003076518,"about_ca_topic_score_gemma":0.0007319046,"domain_scores_codex":[0.9998555,0.00002311071,0.00001188993,0.00003676466,0.00003009153,0.00004264332],"domain_scores_gemma":[0.9998651,0.00002782494,0.0000487028,0.0000188454,0.00001569892,0.00002382755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005354256,0.000007560939,0.00003273328,0.00002797208,0.000002889816,0.00006377856,0.00001934172,0.00003089039,0.9986827,0.0001015778,0.00002589347,0.0009511631],"study_design_scores_gemma":[0.00000548873,0.00006363563,0.0001905539,0.000001124515,0.00000320926,0.00008849326,0.000005540801,0.0001469612,0.9989261,0.00001328055,0.0005533298,0.000002346289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647226,0.0008167392,0.02927112,0.0001128908,0.00005187251,0.00007676386,0.0003156606,0.0002128092,0.00441956],"genre_scores_gemma":[0.9900696,0.0004031122,0.007444712,0.00002813647,0.000007948791,0.00002464266,0.0002123193,0.00003150056,0.00177803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001275387,"threshold_uncertainty_score":0.00426662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041006894130088,"score_gpt":0.2446579537660772,"score_spread":0.2342478848247763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}