{"id":"W2557293680","doi":"10.1182/blood.v126.23.251.251","title":"Homozygosity for the 2R Tandem Repeat Polymorphism in the Thymidylate Synthase (TS) Promoter Is Associated with Increased Risk for Bony Morbidity Among Children Treated for Acute Lymphoblastic Leukemia on DFCI Protocol 05-001","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Internal medicine; Acute lymphocytic leukemia; Single-nucleotide polymorphism; Avascular necrosis; Leukemia; Gastroenterology; Oncology; Surgery; Biology; Genotype; Genetics; Femoral head; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004998408,0.0002070844,0.0002583023,0.0005634669,0.0003735147,0.0002998641,0.0003932686,0.0003024124,0.003027446],"category_scores_gemma":[0.001478366,0.0001553723,0.0002136108,0.0007399102,0.0002015819,0.00009921033,0.0002612508,0.000412233,0.0002552937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003509817,"about_ca_system_score_gemma":0.0004615355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005442753,"about_ca_topic_score_gemma":0.005409039,"domain_scores_codex":[0.9995306,0.0001477421,0.00003901137,0.00008361525,0.0001111677,0.00008799198],"domain_scores_gemma":[0.9990564,0.0002566309,0.0003867975,0.00004329556,0.00007066379,0.0001862592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006557964,0.00007282892,0.9949818,0.00001332113,0.00002939741,0.0001908459,0.00006307376,0.0000468479,0.002077291,0.00002570238,0.0002932451,0.001549897],"study_design_scores_gemma":[0.00004975069,0.0003815262,0.9976913,0.00001026408,0.00004046281,0.000538252,0.0001122783,0.0001348196,0.0006146171,0.00001958102,0.00040413,0.000003046562],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989115,0.0000554693,0.0000652112,0.0000467281,0.000003242689,0.00001707857,0.0005553762,0.000004255289,0.0003411739],"genre_scores_gemma":[0.9985303,0.00006003755,0.0001699908,0.00002979549,0.000006279697,0.00003331544,0.0007944181,0.000004749581,0.0003710959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005442753,"threshold_uncertainty_score":0.01082212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269445031560749,"score_gpt":0.2896708924949645,"score_spread":0.2669764421793571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}