{"id":"W2557351924","doi":"10.1002/cbic.201600538","title":"Fungal Glycolipid Hydrolase Inhibitors and Their Effect on <i>Cryptococcus neoformans</i>","year":2016,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Iminosugar; Cryptococcus neoformans; Glycolipid; Microbiology; Echinocandins; Biology; Antifungal drug; Drug; Enzyme; Biochemistry; Chemistry; Candida albicans; Pharmacology; Antifungal; Amphotericin B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001559693,0.0004710825,0.0001673255,0.0002703577,0.0001521923,0.0002018225,0.0001907717,0.0002586029,0.001604803],"category_scores_gemma":[0.0001111507,0.000122388,0.0001881507,0.0001777758,0.0001553385,0.0001421511,0.0001197767,0.0003718345,0.0003087352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002994927,"about_ca_system_score_gemma":0.000268794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002230948,"about_ca_topic_score_gemma":0.005943692,"domain_scores_codex":[0.9999224,0.0000161744,0.000004471602,0.00000888862,0.00002358785,0.00002445153],"domain_scores_gemma":[0.9999614,0.000008009189,0.00001022069,0.000002452524,0.000006236902,0.00001173544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001001697,0.0003952837,0.001004009,0.0004360924,0.00004061513,0.0002709234,0.00002308788,0.0006961533,0.9243783,0.0004835399,0.001211754,0.07005858],"study_design_scores_gemma":[0.0001213179,0.003412943,0.007972443,0.00005716506,0.00006781634,0.0007847026,0.00002525898,0.0008530857,0.9701579,0.000109327,0.01642418,0.00001393726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8642894,0.1088621,0.002464743,0.001106004,0.0001998614,0.0002180189,0.0008311269,0.0001820778,0.02184671],"genre_scores_gemma":[0.9600553,0.03055206,0.00284537,0.0003488557,0.0000396294,0.00003275269,0.0004591432,0.00001166037,0.005655184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002230948,"threshold_uncertainty_score":0.00536859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006597114110799645,"score_gpt":0.2255957592162241,"score_spread":0.2189986451054244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}