{"id":"W2557351924","doi":"10.1002/cbic.201600538","title":"Fungal Glycolipid Hydrolase Inhibitors and Their Effect on <i>Cryptococcus neoformans</i>","year":2016,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Iminosugar; Cryptococcus neoformans; Glycolipid; Microbiology; Echinocandins; Biology; Antifungal drug; Drug; Enzyme; Biochemistry; Chemistry; Candida albicans; Pharmacology; Antifungal; Amphotericin B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451265,0.0002206717,0.0002947657,0.00006736373,0.0001359024,0.00001408245,0.00003786809,0.0000997143,0.00005022233],"category_scores_gemma":[0.000107,0.0001141852,0.0001094788,0.0001125719,0.0001285226,0.00005547949,0.0000593453,0.0001308983,0.0001206839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006284905,"about_ca_system_score_gemma":0.0000194927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005376877,"about_ca_topic_score_gemma":0.000001597255,"domain_scores_codex":[0.9991716,0.00001638136,0.0001609995,0.0002704686,0.0001028671,0.0002776757],"domain_scores_gemma":[0.9993455,0.0001647224,0.00004118486,0.0002516625,0.00004189389,0.0001550311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005762115,0.0001887769,0.02081651,0.0001692298,0.000148722,0.00002223555,0.0002311715,1.215109e-7,0.9198979,0.0001453317,0.02015201,0.03765174],"study_design_scores_gemma":[0.002117287,0.001390785,0.003844077,0.0002113233,0.00003452551,0.00006389896,0.00003292808,0.000005867327,0.9684039,0.00003382031,0.02370873,0.0001528174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799994,0.0003391698,0.00001400487,0.0009269243,0.0002675935,0.0003704861,0.00001131192,0.0001092143,0.01796194],"genre_scores_gemma":[0.9973971,0.00008186675,0.00001309347,0.0004376097,0.0004614562,0.00007670728,0.000003406934,0.00002215048,0.001506655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.048506,"threshold_uncertainty_score":0.4656338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006597114110799645,"score_gpt":0.2255957592162241,"score_spread":0.2189986451054244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}