{"id":"W2557368926","doi":"10.1097/qad.0000000000001275","title":"Increase in international normalized ratio after switching from atazanavir/ritonavir to darunavir/cobicistat in a patient on warfarin","year":2016,"lang":"en","type":"letter","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Ritonavir; Cobicistat; Darunavir; Pharmacology; CYP2C9; Atazanavir; Warfarin; Medicine; Chemistry; Internal medicine; Viral load; Virology; Cytochrome P450; Atrial fibrillation; Metabolism; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002117424,0.0005824445,0.0007702493,0.0009657475,0.00003582629,0.00005789879,0.000271343,0.0004469784,0.0009381719],"category_scores_gemma":[0.0001095987,0.0004489025,0.0001733133,0.000272247,0.00002855964,0.000178499,0.0002278428,0.00110024,0.0009223517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001158761,"about_ca_system_score_gemma":0.0002242478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002470056,"about_ca_topic_score_gemma":0.0007057878,"domain_scores_codex":[0.9967172,0.0001628137,0.0008304575,0.0008666897,0.0008449594,0.0005778391],"domain_scores_gemma":[0.9987507,0.0002754279,0.0001515593,0.0005892435,0.00005988571,0.0001731734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009096989,0.001425429,0.3605928,0.0001646615,0.001110424,0.03504617,0.008481745,0.000009608329,0.001754215,0.00009296372,0.405113,0.177112],"study_design_scores_gemma":[0.006853785,0.0004066294,0.03230346,0.002880308,0.0001221329,0.00002110673,0.00006462446,0.00003013351,0.0009219666,0.0003003119,0.9553227,0.000772857],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7005411,0.00009560653,0.00007685913,0.2938346,0.0007673102,0.001241324,0.0003708124,0.0000609161,0.003011464],"genre_scores_gemma":[0.6572271,0.00007622204,0.00294311,0.3197345,0.00181792,0.001164013,0.003698634,0.0001521903,0.01318631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5502096,"threshold_uncertainty_score":0.9999751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017647894845287,"score_gpt":0.2601896880689056,"score_spread":0.2500132091204528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}