{"id":"W2557380874","doi":"10.1371/journal.pone.0166973","title":"Beneficial Effects of Metformin and/or Salicylate on Palmitate- or TNFα-Induced Neuroinflammatory Marker and Neuropeptide Gene Regulation in Immortalized NPY/AgRP Neurons","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Banting and Best Diabetes Centre, University of Toronto; Endocrine Society","keywords":"Endocrinology; Metformin; Internal medicine; AMPK; Neuropeptide Y receptor; Neuroinflammation; Sodium salicylate; Proinflammatory cytokine; Chemistry; Tumor necrosis factor alpha; Neuropeptide; Inflammation; Biology; Medicine; Phosphorylation; Protein kinase A; Insulin; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544848,0.0003950406,0.0004495903,0.0002220377,0.0001979978,0.0002175797,0.0002128689,0.0002662326,0.001054161],"category_scores_gemma":[0.0001121013,0.0001561446,0.0003891736,0.0001882752,0.0002153223,0.0002924794,0.0001860717,0.0006199417,0.0001876027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001605653,"about_ca_system_score_gemma":0.0002711393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007465404,"about_ca_topic_score_gemma":0.001526517,"domain_scores_codex":[0.9998441,0.00002467999,0.00003325315,0.00002380806,0.00003229403,0.00004191743],"domain_scores_gemma":[0.9999057,0.00001187504,0.00002618648,0.00001228969,0.00001012471,0.00003380462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001445116,0.0001490652,0.0001971342,0.00006907171,0.00001409818,0.00007610449,0.00002596427,0.00005640044,0.9965678,0.00004084549,0.00003491655,0.001323362],"study_design_scores_gemma":[0.0001312077,0.002466037,0.006481634,0.000008482672,0.00005661679,0.0001689933,0.00007830019,0.0005388465,0.9885886,0.00003844121,0.001435077,0.000007942534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975476,0.001211625,0.0003285945,0.00007952072,0.00005076824,0.00001862707,0.000295795,0.00001959787,0.0004478632],"genre_scores_gemma":[0.994987,0.00169529,0.001033577,0.00005797627,0.00002272103,0.00005203838,0.000558008,0.00001088693,0.00158252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054161,"threshold_uncertainty_score":0.003526568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04617740266257091,"score_gpt":0.2442036606795485,"score_spread":0.1980262580169775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}