{"id":"W2557391554","doi":"10.1182/blood.v106.11.5542.5542","title":"Initiation of a Pre-Clinical Gene Therapy Study in Non-Human Primates Using Lentivectors Targeting Hematopoietic Cells for Correction of Fabry Disease.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Globotriaosylceramide; Leukapheresis; Genetic enhancement; CD34; Apheresis; Haematopoiesis; Stem cell; Hematopoietic stem cell transplantation; Immunology; Medicine; Fabry disease; Biology; Transplantation; Internal medicine; Disease; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001432237,0.000570155,0.0005564163,0.0004812098,0.00060685,0.0004888885,0.000470898,0.000840786,0.003976168],"category_scores_gemma":[0.0004945325,0.0001647026,0.0004363151,0.0002116976,0.0005302936,0.0003154498,0.0003208472,0.001220578,0.001187564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000397194,"about_ca_system_score_gemma":0.0007511586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001287938,"about_ca_topic_score_gemma":0.001484381,"domain_scores_codex":[0.9994953,0.0001709428,0.00002922326,0.00008506291,0.0001268325,0.00009275891],"domain_scores_gemma":[0.9995862,0.00009623527,0.00005062752,0.000068645,0.00007523937,0.00012312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001088264,0.002018924,0.0008133391,0.0001913847,0.00002648371,0.0005427781,0.00031694,0.0002559757,0.9797392,0.0007252857,0.001430354,0.01285095],"study_design_scores_gemma":[0.0006604115,0.0323323,0.009324457,0.00009107062,0.0001302102,0.002035222,0.0002528232,0.001070819,0.8986597,0.0004538115,0.05495756,0.0000316009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9392915,0.003334523,0.03156627,0.0009830624,0.0003744067,0.01111626,0.002696291,0.0006274541,0.01001025],"genre_scores_gemma":[0.9076427,0.003597927,0.04968911,0.0009545026,0.0001945724,0.009567162,0.007145853,0.0002202533,0.02098788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003976168,"threshold_uncertainty_score":0.01330161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03358046671294535,"score_gpt":0.3729107172509217,"score_spread":0.3393302505379764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}