{"id":"W2557392219","doi":"10.1182/blood.v126.23.4213.4213","title":"Prima-1Met Combined with Bortezomib Has Synergistic Anti-Myeloma Activity By Modulation of Apoptosis and Cell Cycle Regulating Genes","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Bortezomib; Multiple myeloma; In vivo; Cytotoxicity; Housekeeping gene; Biology; Apoptosis; Cancer research; Cell culture; Gene expression; Pharmacology; Chemistry; Gene; Immunology; In vitro; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082976,0.0004274712,0.0005439822,0.0003688049,0.0001471917,0.0002901813,0.0001515762,0.0002033316,0.001932049],"category_scores_gemma":[0.00008544479,0.0001516898,0.0003024072,0.0002974391,0.0001879268,0.0001274859,0.0001979276,0.0004359592,0.0003380088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002057499,"about_ca_system_score_gemma":0.0002429362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002502789,"about_ca_topic_score_gemma":0.0005086047,"domain_scores_codex":[0.9998434,0.00002511266,0.00001566584,0.00003607693,0.000048593,0.00003121201],"domain_scores_gemma":[0.9999347,0.00001414502,0.0000162072,0.000007433465,0.000009515275,0.00001804499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006001006,0.00009176115,0.0002455602,0.0001194359,0.00001466594,0.00004202522,0.000009474844,0.00008580653,0.9936908,0.00003387659,0.0001119073,0.004954517],"study_design_scores_gemma":[0.00006512934,0.001335628,0.004001498,0.000007340578,0.00003416697,0.0001955628,0.00001300827,0.000476107,0.9904199,0.00002683561,0.003421179,0.000003680554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982159,0.01151832,0.00210867,0.0002263605,0.0001357973,0.00006919312,0.0007297096,0.0002080805,0.002844928],"genre_scores_gemma":[0.9882139,0.003310581,0.003522368,0.0001314225,0.00005139895,0.0001084465,0.001016446,0.00002607541,0.003619398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001932049,"threshold_uncertainty_score":0.006463349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02752699093899491,"score_gpt":0.2632618762589371,"score_spread":0.2357348853199422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}