{"id":"W2557398232","doi":"10.1016/j.bbadis.2016.11.031","title":"Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy","year":2016,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; McGill University; Alberta Children's Hospital; Centre Hospitalier Universitaire de Sherbrooke; University Health Network; University of Toronto","funders":"H2020 European Research Council; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; Medical University of South Carolina","keywords":"Ceramide; Cytokine; Medicine; Hematopoietic stem cell transplantation; Internal medicine; Sphingolipid; Endocrinology; Proinflammatory cytokine; Immunology; Acid sphingomyelinase; Transplantation; Biology; Inflammation; Sphingomyelin; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103083,0.0005633589,0.0004153146,0.0004349675,0.0001840675,0.0002120646,0.0001696055,0.0003995681,0.0007633148],"category_scores_gemma":[0.0002741984,0.0001116388,0.0001516389,0.0002948087,0.0004015289,0.0001886861,0.0002728285,0.0003322294,0.0002180453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000156546,"about_ca_system_score_gemma":0.0001540655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002034388,"about_ca_topic_score_gemma":0.0001530322,"domain_scores_codex":[0.9998971,0.00001883067,0.00002017873,0.00002299833,0.00002167504,0.00001915501],"domain_scores_gemma":[0.9998811,0.00002107083,0.00005065029,0.000007423298,0.000007988607,0.00003169508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005482144,0.0002090842,0.02788509,0.0002763117,0.00007268027,0.04259772,0.000167298,0.0001384259,0.8965142,0.0007923899,0.0004115117,0.02545317],"study_design_scores_gemma":[0.0006197912,0.005295105,0.2484611,0.0001265466,0.0003630244,0.4283154,0.0004849939,0.001460133,0.2951647,0.002272832,0.01737569,0.00006074933],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934337,0.003045079,0.00148796,0.0001657809,0.00003250514,0.00003371919,0.0002418711,0.00004269527,0.001516687],"genre_scores_gemma":[0.9974395,0.001110621,0.0005931178,0.00006171955,0.0000328327,0.00002041378,0.0002680909,0.000007603065,0.0004661235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007633148,"threshold_uncertainty_score":0.002553582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346793777189553,"score_gpt":0.261556132670591,"score_spread":0.2480881948986955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}