{"id":"W2557428466","doi":"10.1182/blood.v114.22.4756.4756","title":"Clinical Development of MGCD0103, An Isotype-Selective HDAC Inhibitor: Pericarditis/Pericardial Effusion in the Context of Overall Safety and Efficacy.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Medicine; Internal medicine; Neutropenia; Gastroenterology; Context (archaeology); Tolerability; Adverse effect; Febrile neutropenia; Anemia; Oncology; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001806155,0.0005431408,0.0008911591,0.0002576588,0.0002825478,0.000669981,0.0007160669,0.001056852,0.002538806],"category_scores_gemma":[0.0009973856,0.0001573252,0.0005605593,0.0004126862,0.0003813786,0.0004036616,0.000294382,0.001230485,0.0006493008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007806516,"about_ca_system_score_gemma":0.001427058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009562497,"about_ca_topic_score_gemma":0.00280989,"domain_scores_codex":[0.9996431,0.0001401782,0.00003106629,0.00005237871,0.00005562025,0.000077577],"domain_scores_gemma":[0.9995998,0.00005581636,0.00008419753,0.0000379773,0.00006282674,0.0001594374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.07689835,0.009525023,0.02131158,0.002002918,0.0006099364,0.001600228,0.0004081691,0.002031177,0.2110769,0.001701807,0.01300302,0.6598308],"study_design_scores_gemma":[0.1094764,0.5256401,0.1142695,0.0005374039,0.001563024,0.01026688,0.0002332628,0.00472869,0.10296,0.001249396,0.1289825,0.00009278305],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9138365,0.05907622,0.003521814,0.002044832,0.0003736671,0.00355466,0.002138572,0.0004204782,0.01503315],"genre_scores_gemma":[0.9812965,0.009030264,0.003026277,0.001462605,0.0002202571,0.0007013961,0.001994319,0.00004278332,0.002225583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002538806,"threshold_uncertainty_score":0.009552002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129292443824398,"score_gpt":0.3053250331894924,"score_spread":0.2923957888070526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}