{"id":"W2557493613","doi":"10.1101/gr.210930.116","title":"Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes","year":2016,"lang":"en","type":"article","venue":"Genome Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Enhancer; Biology; Enhancer RNAs; Gene; Regulation of gene expression; Genetics; Transcription factor; Embryonic stem cell; Transcription (linguistics); Enhancer trap; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002484451,0.0003145951,0.0002968427,0.000221776,0.0001388769,0.0003892291,0.0003295715,0.0002655922,0.001722417],"category_scores_gemma":[0.0002137196,0.0002062397,0.0003321112,0.0001319171,0.0003967382,0.0003235339,0.0004666034,0.0006473168,0.0006068358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002616844,"about_ca_system_score_gemma":0.000215013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002636623,"about_ca_topic_score_gemma":0.000445436,"domain_scores_codex":[0.9996457,0.00003030426,0.0000233049,0.0001626377,0.0001045596,0.00003343157],"domain_scores_gemma":[0.9997864,0.00004370684,0.00005638808,0.00004667003,0.0000215723,0.00004519822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005826109,0.00001100031,0.0004123955,0.00004608015,0.000006535473,0.00005124996,0.00001745612,0.000171347,0.9945504,0.0006497692,0.00002583726,0.003999687],"study_design_scores_gemma":[0.00002520803,0.0002171131,0.009768905,0.00002843873,0.00005767321,0.0006946544,0.00004714109,0.002595537,0.967363,0.0009665841,0.01822047,0.00001526989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9141663,0.008834057,0.06988661,0.0001860327,0.0001235572,0.00006769577,0.0007208565,0.0005662294,0.005448521],"genre_scores_gemma":[0.9696659,0.002135845,0.02021631,0.0001360611,0.00002821089,0.00004848825,0.001087994,0.0001055053,0.006575673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001722417,"threshold_uncertainty_score":0.0057621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04541640723268544,"score_gpt":0.3050515763144328,"score_spread":0.2596351690817474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}