{"id":"W2557493613","doi":"10.1101/gr.210930.116","title":"Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes","year":2016,"lang":"en","type":"article","venue":"Genome Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Enhancer; Biology; Enhancer RNAs; Gene; Regulation of gene expression; Genetics; Transcription factor; Embryonic stem cell; Transcription (linguistics); Enhancer trap; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006304018,0.0001431125,0.0001889001,0.0001017938,0.0000832053,0.00002427271,0.0002491062,0.0001728132,0.00005097728],"category_scores_gemma":[0.00002236161,0.0001111251,0.00004590106,0.0001179397,0.0002707238,0.00001621783,0.0002321062,0.00008010626,0.000006778203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001634677,"about_ca_system_score_gemma":0.0002007784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006978084,"about_ca_topic_score_gemma":0.0004929118,"domain_scores_codex":[0.9983287,0.0001786642,0.0002806562,0.0004815757,0.0002793744,0.0004510613],"domain_scores_gemma":[0.999086,0.00005238004,0.00007524423,0.0005285953,0.0001626921,0.00009511752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002241534,0.00007377427,0.001160478,0.00006618323,0.00002161555,0.000001362132,0.0003291584,0.0002406815,0.9888197,0.00003270803,0.00001920126,0.009011041],"study_design_scores_gemma":[0.0008462993,0.0008236999,0.005944188,0.00004561545,0.000004509221,0.000003869194,0.001098684,0.0004835154,0.9883407,0.0002446724,0.001979353,0.0001848725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965868,0.002261208,0.0004326428,0.00005527432,0.000048085,0.0003204301,0.00004014108,0.000005728999,0.0002497059],"genre_scores_gemma":[0.9954123,0.001856567,0.0006836059,0.000007963103,0.00009823014,0.00002988905,0.00002584324,0.00003321212,0.001852316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008826169,"threshold_uncertainty_score":0.4531551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04541640723268544,"score_gpt":0.3050515763144328,"score_spread":0.2596351690817474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}