{"id":"W2557504094","doi":"10.1182/blood.v118.21.1856.1856","title":"Novel AKT Inhibitor GSK2110183 Shows Favorable Safety, Pharmacokinetics, and Clinical Activity in Multiple Myeloma. Preliminary Results From a Phase I First-Time-In-Human Study","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Chronic lymphocytic leukemia; Multiple myeloma; Internal medicine; Pharmacokinetics; Lenalidomide; Neutropenia; Lymphoma; Pharmacology; Oncology; Toxicity; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001163598,0.001241294,0.001393392,0.000366854,0.0003733317,0.0006594537,0.0006199214,0.000579283,0.001733857],"category_scores_gemma":[0.0004666102,0.0004676393,0.0008137531,0.0005919362,0.0006461472,0.0004813656,0.0002167072,0.00177977,0.0005614338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008261395,"about_ca_system_score_gemma":0.001206019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001562372,"about_ca_topic_score_gemma":0.004575145,"domain_scores_codex":[0.9997585,0.00007289075,0.00001741179,0.00003288036,0.00005160892,0.00006668647],"domain_scores_gemma":[0.9996855,0.00006358679,0.00008441242,0.00003397393,0.00002432775,0.0001082337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1535862,0.05715727,0.02063128,0.001709113,0.00150223,0.001603733,0.0006836621,0.00763269,0.4825255,0.0003673499,0.01127944,0.2613214],"study_design_scores_gemma":[0.1250304,0.6569966,0.0829071,0.0001088922,0.001233775,0.003524956,0.000128263,0.004171441,0.1155881,0.0003353759,0.009875703,0.00009938399],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913873,0.004162366,0.0008376928,0.0003103912,0.0000394948,0.0006033675,0.0009728561,0.000190881,0.001495603],"genre_scores_gemma":[0.9887776,0.003193629,0.002167957,0.0003575943,0.00006667784,0.000463724,0.003180236,0.00005219672,0.00174033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001733857,"threshold_uncertainty_score":0.006153762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05237532207231623,"score_gpt":0.3222238660342339,"score_spread":0.2698485439619177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}