{"id":"W2557528909","doi":"10.1107/s2053273314091724","title":"Structural and functional studies of Sacsin","year":2014,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations and Advances","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cytoplasm; Gene; AAA proteins; Biology; Proteasome; Genetics; Mutation; Protein domain; Cell biology; Population; ATPase; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004065262,0.0004457924,0.0003692278,0.00022129,0.0004041205,0.0003061625,0.0005705033,0.0004400549,0.001945526],"category_scores_gemma":[0.0003894666,0.0001566523,0.000382439,0.0004916284,0.0003011445,0.0003781547,0.0002097619,0.0008214962,0.0004347298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008322868,"about_ca_system_score_gemma":0.0004959324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005919893,"about_ca_topic_score_gemma":0.00447499,"domain_scores_codex":[0.9998537,0.00002099464,0.00001091386,0.00003075367,0.00005377923,0.00002982762],"domain_scores_gemma":[0.9997544,0.00004329953,0.00003731963,0.00001369917,0.0000664043,0.00008492801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000915138,0.0002084533,0.002287523,0.0005838368,0.00009006197,0.001203083,0.000421302,0.002846548,0.9733845,0.002802319,0.001714799,0.01354241],"study_design_scores_gemma":[0.0002247484,0.00128359,0.05627148,0.0001015609,0.0002001095,0.003645096,0.0005587431,0.01946765,0.7930766,0.001516122,0.1235321,0.0001222105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829385,0.008956343,0.002490989,0.0004378932,0.0001954167,0.00002174488,0.0008267471,0.00007503761,0.0040574],"genre_scores_gemma":[0.9841814,0.00409185,0.003910858,0.0001427981,0.00005723972,0.00001083471,0.003861285,0.00002692535,0.003716855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005919893,"threshold_uncertainty_score":0.0117709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03540683332534719,"score_gpt":0.2927944296661639,"score_spread":0.2573875963408168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}