{"id":"W2557587008","doi":"10.1194/jlr.p065250","title":"Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36","year":2016,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Cooperative State Research, Education, and Extension Service; National Institutes of Health; National Institute for Health and Care Research; Longer Life Foundation; Georgia Clinical and Translational Science Alliance; Broad Institute; Harvard University; American Heart Association","keywords":"Chylomicron; CD36; Postprandial; DNA methylation; Single-nucleotide polymorphism; Biology; Methylation; Lipid metabolism; Promoter; Internal medicine; Endocrinology; Genetics; Gene expression; Lipoprotein; Gene; Genotype; Cholesterol; Medicine; Very low-density lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001462041,0.0001232334,0.0001916169,0.00008972084,0.0001344856,0.00007017743,0.0001346664,0.0001597998,0.00004949904],"category_scores_gemma":[0.0003348946,0.00007352372,0.00004039131,0.0001366116,0.0002193886,0.00003860689,0.000110069,0.0002509817,0.000004647013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006493158,"about_ca_system_score_gemma":0.0001335593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006562746,"about_ca_topic_score_gemma":0.000007683813,"domain_scores_codex":[0.9984051,0.0003503831,0.0002278345,0.0002349567,0.0004228588,0.000358843],"domain_scores_gemma":[0.9989751,0.00009995569,0.0001873005,0.0001542746,0.0003368272,0.0002465585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005181998,0.0000425948,0.06190757,0.00001162841,0.0001104766,0.000005113341,0.00007616642,4.668873e-7,0.932175,0.000005519965,0.002027555,0.003119735],"study_design_scores_gemma":[0.001265171,0.0005915256,0.02419671,0.00007378277,0.00001245934,0.00005315334,0.00009425842,0.000002059028,0.9663189,0.0000671607,0.007209885,0.0001149542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964761,0.0008990707,0.00001995181,0.002189198,0.0001021415,0.0001064147,0.000006497911,0.000004014521,0.0001966169],"genre_scores_gemma":[0.9967376,0.001374501,0.0003162304,0.00004123942,0.0004600755,0.000003757816,0.000001886953,0.00002431868,0.001040405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03771086,"threshold_uncertainty_score":0.299821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05518393532864242,"score_gpt":0.339077164162197,"score_spread":0.2838932288335546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}