{"id":"W2557600559","doi":"10.1182/blood.v116.21.792.792","title":"Small Molecule SHIP Agonist AQX-MN100 Inhibits Multiple Myeloma (MM) Cell Growth In NOD/SCID Mice and Reduces Immune Suppressive Myeloid Derived Suppressor Cells (MDSC) and Regulatory T Cells (Tregs) In Mouse Model","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Biology; Haematopoiesis; Cancer research; Cell biology; Signal transduction; Myeloid; Immune system; Phosphoinositide 3-kinase; Stem cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000176719,0.0004889609,0.0005599966,0.000193371,0.0001579775,0.0001995418,0.0004194001,0.0004017579,0.0001043755],"category_scores_gemma":[0.00006841157,0.0005256335,0.00009678262,0.0001209604,0.0002297951,0.0002334504,0.0003218165,0.0005590611,0.000009489938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002938847,"about_ca_system_score_gemma":0.00007230109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001251596,"about_ca_topic_score_gemma":0.0001752519,"domain_scores_codex":[0.9975119,0.00007296499,0.000703892,0.0008677018,0.0002586642,0.0005848344],"domain_scores_gemma":[0.9986143,0.0002399837,0.0003119978,0.0005266014,0.00007843091,0.0002286804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000109349,0.0007407549,0.002518803,0.0002260872,0.00002575662,0.00002855694,0.001316058,0.00002000675,0.9948866,0.000007859079,0.00001449168,0.0001056653],"study_design_scores_gemma":[0.003567913,0.00002358489,0.002756165,0.0001119002,0.00004444591,0.0000178337,0.0003475374,0.002358505,0.9901242,0.00003563912,0.00003310741,0.0005792285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979413,0.0003118702,0.00001109444,0.0001096821,0.0000807356,0.0002408057,0.0001620221,0.00007682674,0.001065671],"genre_scores_gemma":[0.9977586,0.0001571121,0.0009859543,0.00005591328,0.0000886944,0.00007695146,0.00008542414,0.00009303232,0.0006983256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004762472,"threshold_uncertainty_score":0.9997195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009112518230682782,"score_gpt":0.1874586015459727,"score_spread":0.1783460833152899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}