{"id":"W2557683813","doi":"10.1038/ncomms13555","title":"Increased DNA methylation variability in type 1 diabetes across three immune effector cell types","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre; McGill Genome Centre","funders":"Vetenskapsrådet; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; European Commission; National Institute for Health and Care Research; Medical Research Council; European Molecular Biology Laboratory; NIHR Cambridge Biomedical Research Centre; British Heart Foundation; Wellcome Trust; NHS Blood and Transplant","keywords":"Epigenetics; Epigenome; Biology; DNA methylation; Effector; CpG site; Immune system; Genetics; Epigenomics; Cell type; Monozygotic twin; Gene; Immunology; Cell; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306426,0.0001202752,0.0002579759,0.000606098,0.0001948046,0.0002980227,0.0001301173,0.0002087115,0.00140884],"category_scores_gemma":[0.0005824177,0.000119341,0.000234879,0.0005673973,0.0001540796,0.00008485441,0.0003057556,0.0001911757,0.0001173632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001094678,"about_ca_system_score_gemma":0.00008936766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00234276,"about_ca_topic_score_gemma":0.003911469,"domain_scores_codex":[0.9997839,0.00004089089,0.00001660127,0.00009493425,0.00003615566,0.00002752548],"domain_scores_gemma":[0.9997548,0.0000652734,0.00008855983,0.00002954883,0.00002907272,0.00003267683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001438233,0.00003022428,0.657127,0.0001062962,0.0004931833,0.0001717775,0.0005064238,0.0002173507,0.3235368,0.000145488,0.0001321842,0.01609506],"study_design_scores_gemma":[0.000006413575,0.0000763046,0.9922411,0.000005538029,0.0001052756,0.0003692713,0.00008156605,0.0001906752,0.006527155,0.000106671,0.0002854934,0.000004461804],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984245,0.0004700352,0.0004580932,0.00001487707,0.000002882066,0.000002648028,0.0003186091,0.000006574629,0.00030171],"genre_scores_gemma":[0.9990407,0.000137267,0.0003100959,0.00001682809,0.000002631245,0.000003460039,0.000251704,0.000004541478,0.0002328628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00234276,"threshold_uncertainty_score":0.004713058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006352996883354542,"score_gpt":0.264797371741343,"score_spread":0.2584443748579885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}