{"id":"W2557683813","doi":"10.1038/ncomms13555","title":"Increased DNA methylation variability in type 1 diabetes across three immune effector cell types","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre; McGill Genome Centre","funders":"Vetenskapsrådet; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; European Commission; National Institute for Health and Care Research; Medical Research Council; European Molecular Biology Laboratory; NIHR Cambridge Biomedical Research Centre; British Heart Foundation; Wellcome Trust; NHS Blood and Transplant","keywords":"Epigenetics; Epigenome; Biology; DNA methylation; Effector; CpG site; Immune system; Genetics; Epigenomics; Cell type; Monozygotic twin; Gene; Immunology; Cell; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006478133,0.0001111009,0.0001303026,0.00002621793,0.0001041615,0.00001766183,0.000530483,0.0003453296,0.00001092838],"category_scores_gemma":[0.0009532979,0.00008580838,0.0000654327,0.0002079538,0.00009304182,0.000008135081,0.0002718856,0.0002179231,0.00001799564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003167137,"about_ca_system_score_gemma":0.000039058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002851939,"about_ca_topic_score_gemma":0.000783401,"domain_scores_codex":[0.9990572,0.0002819429,0.000175502,0.0001990297,0.00007326601,0.0002130732],"domain_scores_gemma":[0.9983453,0.000288501,0.00008621726,0.001115839,0.0001263089,0.00003785092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001825362,0.0001857644,0.1533982,0.000008339836,0.00003685931,4.878939e-8,0.00002293492,0.000002171315,0.8377038,0.0001857933,0.0004111882,0.008026643],"study_design_scores_gemma":[0.001523037,0.000148595,0.6140407,0.00005025271,0.00003860343,1.219339e-7,0.00003082724,0.0001305896,0.3380952,0.001163475,0.04439149,0.0003871047],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903041,0.007049582,0.00004714207,0.0008376691,0.0001089319,0.0001989297,0.00007867248,0.00002070345,0.001354228],"genre_scores_gemma":[0.9984547,0.0005049231,0.0004390402,0.0001292462,0.0000276748,0.00003365644,0.0003325818,0.0000154917,0.00006261239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4996086,"threshold_uncertainty_score":0.3499164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006352996883354542,"score_gpt":0.264797371741343,"score_spread":0.2584443748579885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}