{"id":"W2557711954","doi":"10.1038/srep38177","title":"Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Consejo Nacional de Ciencia y Tecnología; National Institutes of Health; Eusko Jaurlaritza","keywords":"Epitope; Neutralization; Membrane; Antibody; Biophysics; Helix (gastropod); Transmembrane protein; Gp41; Transmembrane domain; Chemistry; Virology; Biology; Biochemistry; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306733,0.0002332123,0.0001521782,0.0000894304,0.0001594609,0.0002204819,0.000288349,0.0003789514,0.0009223827],"category_scores_gemma":[0.0001533229,0.0001536828,0.0001769343,0.00005458824,0.0002583372,0.000210118,0.0002308963,0.0004793201,0.0003334612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00023523,"about_ca_system_score_gemma":0.0002343183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003520791,"about_ca_topic_score_gemma":0.000265661,"domain_scores_codex":[0.9999406,0.00001160212,0.000004347973,0.0000086583,0.00001551522,0.00001931409],"domain_scores_gemma":[0.9999368,0.00001438423,0.00001923622,0.000004824513,0.000009331761,0.00001551812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001896408,0.00005915314,0.001465451,0.00003966354,0.000008487988,0.0003408692,0.00002957233,0.001114997,0.994545,0.0008192961,0.00004592087,0.001341941],"study_design_scores_gemma":[0.0001634949,0.0007949125,0.02115348,0.00003273991,0.00004133183,0.002385958,0.0002098907,0.01712845,0.9527428,0.002553072,0.002771085,0.00002273141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959764,0.0003799794,0.002474236,0.0001200219,0.000008437336,0.00001581642,0.0000402658,0.00002538692,0.000959515],"genre_scores_gemma":[0.9980971,0.0001661459,0.001381356,0.00005614868,0.000003244117,0.000006584262,0.00005689697,0.000003004773,0.0002295604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009223827,"threshold_uncertainty_score":0.003085673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02474654724126039,"score_gpt":0.2865427025609039,"score_spread":0.2617961553196435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}