{"id":"W2557809228","doi":"10.1007/s00204-016-1900-y","title":"Patulin transformation products and last intermediates in its biosynthetic pathway, E- and Z-ascladiol, are not toxic to human cells","year":2016,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Mycotoxins in Agriculture and Food","field":"Agricultural and Biological Sciences","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Centre National de la Recherche Scientifique; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Conseil National de la Recherche Scientifique; Agence Nationale de la Recherche","keywords":"Patulin; Mycotoxin; Biotransformation; Penicillium expansum; Chemistry; Biochemistry; Mutant; Cytotoxicity; Biology; Microbiology; Food science; In vitro; Enzyme; Botany; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507029,0.0002651633,0.0001795475,0.0002743948,0.0002268869,0.0005057862,0.0001380267,0.0003331282,0.002780036],"category_scores_gemma":[0.0003301099,0.0001409074,0.0002442915,0.0002756455,0.0002750003,0.000329542,0.000247297,0.0004214154,0.0007276245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001398068,"about_ca_system_score_gemma":0.000344552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005886076,"about_ca_topic_score_gemma":0.0004433881,"domain_scores_codex":[0.9998205,0.00005163625,0.00001470844,0.00003865466,0.0000377539,0.00003670964],"domain_scores_gemma":[0.999743,0.00007133715,0.00004387868,0.00006407606,0.00004007281,0.00003768708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006210783,0.00004534285,0.001236371,0.00003502748,0.00001723119,0.000289092,0.00003755679,0.00003837892,0.9939785,0.000155252,0.00004595896,0.0035002],"study_design_scores_gemma":[0.00001235617,0.0003196134,0.003994459,0.000003416026,0.00002134884,0.0006327217,0.00005510579,0.0001000516,0.9919848,0.00005251335,0.002821127,0.000002503691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908453,0.001883643,0.002740463,0.00007929134,0.0000286288,0.0000282671,0.0003982066,0.00006657957,0.003929738],"genre_scores_gemma":[0.994247,0.0004677222,0.0007851197,0.00002588399,0.000004888858,0.00001320954,0.001083681,0.00001201655,0.003360574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002780036,"threshold_uncertainty_score":0.009300172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441639274276149,"score_gpt":0.2079752508045795,"score_spread":0.193558858061818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}