{"id":"W2557809228","doi":"10.1007/s00204-016-1900-y","title":"Patulin transformation products and last intermediates in its biosynthetic pathway, E- and Z-ascladiol, are not toxic to human cells","year":2016,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Mycotoxins in Agriculture and Food","field":"Agricultural and Biological Sciences","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Centre National de la Recherche Scientifique; Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche; Conseil National de la Recherche Scientifique; Agence Nationale de la Recherche","keywords":"Patulin; Mycotoxin; Biotransformation; Penicillium expansum; Chemistry; Biochemistry; Mutant; Cytotoxicity; Biology; Microbiology; Food science; In vitro; Enzyme; Botany; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011442,0.0001243913,0.0002213236,0.00004289464,0.00005640053,0.00001089659,0.0001440642,0.00007725296,0.00003223584],"category_scores_gemma":[0.00006330817,0.00004251316,0.00002831502,0.0001106706,0.000120954,0.00006547293,0.00007753265,0.00006882102,0.000007632631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005832052,"about_ca_system_score_gemma":0.00000337099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008973069,"about_ca_topic_score_gemma":0.001335316,"domain_scores_codex":[0.9991057,0.00009220684,0.0002422084,0.0002716537,0.00006528726,0.0002229693],"domain_scores_gemma":[0.9995176,0.0002573682,0.00008035401,0.00004471318,0.00001560096,0.00008441981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004013142,0.00007893139,0.001884192,0.00002480535,0.000005027724,0.000001964198,0.0007201079,2.760043e-7,0.9359365,0.0004984604,0.00002469151,0.06078492],"study_design_scores_gemma":[0.0002355409,0.0008496422,0.2875887,0.0001053923,0.000004554043,0.000008751456,0.0002207183,0.000003185283,0.7088153,0.0005755485,0.001461305,0.000131369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994554,0.0001065057,0.00000186854,0.004403942,0.00005620989,0.0003238538,0.00007769867,0.00001663557,0.000459316],"genre_scores_gemma":[0.9994491,0.0001353336,0.00007192498,0.0001712772,0.0000690611,0.00002297143,0.000005329327,9.958962e-7,0.00007404434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2857045,"threshold_uncertainty_score":0.1733636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441639274276149,"score_gpt":0.2079752508045795,"score_spread":0.193558858061818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}