{"id":"W2557947909","doi":"10.1039/c6ob02247b","title":"Structure–activity relationship of novel macrocyclic biased apelin receptor agonists","year":2016,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canada Foundation for Innovation; Merck Sharp and Dohme; Université de Sherbrooke; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Chemistry; Apelin; Receptor; Stereochemistry; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001012019,0.0002249794,0.0002753208,0.0001705456,0.00007635996,0.000143873,0.0002406179,0.0001660367,0.001934616],"category_scores_gemma":[0.0001398558,0.00008930504,0.0001353455,0.0001318277,0.00009231851,0.0001319033,0.0001337447,0.0003034857,0.000329785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001423849,"about_ca_system_score_gemma":0.00011427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00031267,"about_ca_topic_score_gemma":0.0008707183,"domain_scores_codex":[0.9999386,0.00001428723,0.000006323217,0.00001388928,0.00001096206,0.00001596006],"domain_scores_gemma":[0.9999373,0.00001057286,0.00001798846,0.00000470443,0.00000983732,0.00001948012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005951668,0.0001553592,0.0002360551,0.0001628632,0.00003661209,0.0001721959,0.00003908581,0.0009431273,0.9895577,0.0002431039,0.0001604578,0.007698315],"study_design_scores_gemma":[0.0003053723,0.01370686,0.00770897,0.0000311287,0.0001442353,0.000761898,0.0000640734,0.002690936,0.9621935,0.0001470992,0.0122019,0.00004407305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903924,0.004457981,0.001520519,0.00006462841,0.00003536603,0.00009653365,0.0003755506,0.00004447288,0.003012363],"genre_scores_gemma":[0.9921348,0.003108625,0.001925599,0.0001219478,0.00001436499,0.00006988119,0.0004934435,0.000008900934,0.002122489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001934616,"threshold_uncertainty_score":0.006471932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137767330920452,"score_gpt":0.295752321531305,"score_spread":0.2743746482221005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}