{"id":"W2558012555","doi":"10.1038/leu.2016.366","title":"Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma","year":2016,"lang":"en","type":"article","venue":"Leukemia","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"Collège Boréal","funders":"","keywords":"Neuroblastoma RAS viral oncogene homolog; KRAS; Genetic heterogeneity; Cancer research; Biopsy; Tumour heterogeneity; Multiple myeloma; Liquid biopsy; Bone marrow; Digital polymerase chain reaction; Mutation; Biology; Pathology; Medicine; Internal medicine; Oncology; Cancer; Polymerase chain reaction; Gene; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008931375,0.0001426479,0.0001480909,0.00007187862,0.0000561641,0.00002813878,0.0001065761,0.00006884026,0.0000233904],"category_scores_gemma":[0.0001036372,0.0001074094,0.00009730556,0.0001363467,0.00008077086,0.000005874143,0.00005483537,0.00004496525,0.000005164926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001321264,"about_ca_system_score_gemma":0.0003548061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002314979,"about_ca_topic_score_gemma":0.003519508,"domain_scores_codex":[0.9990935,0.00003467022,0.0001732801,0.0003519787,0.0001338938,0.0002127172],"domain_scores_gemma":[0.9994492,0.00005459331,0.0000934215,0.0002268375,0.00004900592,0.0001269466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002154657,0.00002779568,0.8342395,0.00001156562,0.0001816198,0.000138238,0.00002047808,0.004830694,0.1569031,0.00008038867,0.00005307437,0.00329802],"study_design_scores_gemma":[0.0009421114,0.00007288778,0.8912202,0.00002973368,0.0001379122,0.00001828609,0.00002263205,0.001054642,0.1058453,0.0001788634,0.0002230026,0.000254441],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922281,0.0002038672,0.007065892,0.0001191822,0.00003652872,0.00009722478,0.0001158931,0.000008428156,0.0001248853],"genre_scores_gemma":[0.9989931,0.00004603441,0.0004522268,0.0001430775,0.0001242295,0.00002391697,0.0001505927,0.00001666763,0.00005016157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05698071,"threshold_uncertainty_score":0.4380028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009532461115117703,"score_gpt":0.2307855792505649,"score_spread":0.2212531181354472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}