{"id":"W2558218487","doi":"10.1038/onc.2016.433","title":"Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Cancer Research UK; Dan L. Duncan Cancer Center, Baylor College of Medicine; Cancer Prevention and Research Institute of Texas; Congressionally Directed Medical Research Programs; Breast Cancer Research Foundation; BC Cancer Agency; Susan G. Komen for the Cure","keywords":"Biology; Cancer research; Histone acetyltransferase; Epigenetics; Estrogen receptor; Breast cancer; Chromatin immunoprecipitation; Estrogen receptor alpha; Ectopic expression; FOXA1; Histone; Chromatin; Oncogene; Carcinogenesis; Cancer; Molecular biology; Gene expression; Promoter; Gene; Genetics; Cell cycle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009230373,0.0001809599,0.0002099584,0.0002849422,0.0001744418,0.0002064118,0.0001829506,0.0002571378,0.001060862],"category_scores_gemma":[0.0001415957,0.0001259139,0.0003365635,0.0003324832,0.0001684345,0.0001477618,0.0002495795,0.0003732965,0.0002749531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002784957,"about_ca_system_score_gemma":0.0001788575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003447679,"about_ca_topic_score_gemma":0.0006948824,"domain_scores_codex":[0.9999247,0.000004033267,0.00000566747,0.00002251907,0.00002965051,0.00001335612],"domain_scores_gemma":[0.9999365,0.000005834354,0.00002367199,0.000006045952,0.000009937659,0.00001800398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001057594,0.00001255809,0.002920236,0.0000608195,0.00001523181,0.0003685607,0.00001903185,0.00007669383,0.9915007,0.0001751628,0.0001788178,0.004566245],"study_design_scores_gemma":[0.00005398017,0.0003921065,0.08754966,0.00001542139,0.000123449,0.007934704,0.00008418587,0.00379042,0.8822773,0.0002959355,0.01745502,0.00002774461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882536,0.002748116,0.005583358,0.0002583604,0.00006873324,0.00003985608,0.001350339,0.0001904814,0.001507227],"genre_scores_gemma":[0.9910496,0.001146793,0.003408384,0.0001534268,0.0000180042,0.0000220862,0.002526941,0.00002369408,0.001651078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001060862,"threshold_uncertainty_score":0.00354898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0068956134500208,"score_gpt":0.2629519103307026,"score_spread":0.2560562968806818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}