{"id":"W2558218487","doi":"10.1038/onc.2016.433","title":"Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Cancer Research UK; Dan L. Duncan Cancer Center, Baylor College of Medicine; Cancer Prevention and Research Institute of Texas; Congressionally Directed Medical Research Programs; Breast Cancer Research Foundation; BC Cancer Agency; Susan G. Komen for the Cure","keywords":"Biology; Cancer research; Histone acetyltransferase; Epigenetics; Estrogen receptor; Breast cancer; Chromatin immunoprecipitation; Estrogen receptor alpha; Ectopic expression; FOXA1; Histone; Chromatin; Oncogene; Carcinogenesis; Cancer; Molecular biology; Gene expression; Promoter; Gene; Genetics; Cell cycle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124293,0.0001038697,0.0001556923,0.00005561095,0.00001402638,0.000002818235,0.0001362503,0.0001648102,0.00002914969],"category_scores_gemma":[0.00002993179,0.00007687825,0.00007286041,0.0001128836,0.00007374024,0.000003685055,0.00003990664,0.00003843546,0.000008026749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002777565,"about_ca_system_score_gemma":0.0001326395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001510593,"about_ca_topic_score_gemma":0.00001600594,"domain_scores_codex":[0.9991836,0.00003408966,0.0002954726,0.0002274779,0.0001103486,0.0001490237],"domain_scores_gemma":[0.9994079,0.00001333345,0.000191354,0.0002534234,0.0000826409,0.00005130196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001512702,0.0001345881,0.003511098,0.00002334057,0.0000646676,9.921029e-7,0.00002253584,0.00001645447,0.9887761,0.00006500418,0.00004777104,0.007186218],"study_design_scores_gemma":[0.0009056733,0.0001192658,0.01215403,0.00007010862,0.00002085289,0.00001226747,0.00001171418,0.000005705028,0.9863542,0.00004408823,0.0002036915,0.00009836403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977439,0.0009792348,0.0005429697,0.0001661412,0.00009641462,0.0001586606,0.0001148412,0.000003794765,0.0001940441],"genre_scores_gemma":[0.9988294,0.0006212919,0.00007315635,0.00002338251,0.00005844617,0.00002834216,0.00001508432,0.00001721722,0.0003336649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00864293,"threshold_uncertainty_score":0.3135004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0068956134500208,"score_gpt":0.2629519103307026,"score_spread":0.2560562968806818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}