{"id":"W2558360748","doi":"10.1016/s0140-6736(16)32389-3","title":"Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial","year":2016,"lang":"en","type":"article","venue":"The Lancet","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":602,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"AstraZeneca","keywords":"Anastrozole; Fulvestrant; Medicine; Internal medicine; Hazard ratio; Breast cancer; Oncology; Clinical endpoint; Population; Placebo; Aromatase inhibitor; Metastatic breast cancer; Cancer; Gynecology; Randomized controlled trial; Estrogen receptor; Tamoxifen; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004040473,0.0003379757,0.0007709395,0.00008745256,0.0001611541,0.00004206971,0.0004919766,0.0001006819,0.0004099207],"category_scores_gemma":[0.00006137117,0.0001970381,0.0002128106,0.000155613,0.0002603994,0.0005401084,0.00004629786,0.0002077077,0.00002682193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003276011,"about_ca_system_score_gemma":0.0001888759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000725434,"about_ca_topic_score_gemma":0.00004998942,"domain_scores_codex":[0.997995,0.00007944641,0.0004365354,0.0005049037,0.0003893116,0.0005947708],"domain_scores_gemma":[0.9981545,0.0003221635,0.0002855678,0.0007148891,0.0003116397,0.0002112695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8069151,0.0002674431,0.00003374582,0.00001257086,0.0004969152,0.00000465542,0.0002382856,0.00001958472,0.07362571,0.0003398029,0.0008609623,0.1171852],"study_design_scores_gemma":[0.9508999,0.001876206,0.0005531575,0.0001904401,0.0002289251,0.00003572273,0.0002138267,0.00005480605,0.01070174,0.0001429965,0.03480392,0.0002983827],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596859,0.0008024973,0.004818618,0.02436425,0.002495095,0.004128071,0.002723836,0.0002158706,0.0007658394],"genre_scores_gemma":[0.9843453,0.001035237,0.002020671,0.0008446562,0.008925488,0.001793424,0.0002430243,0.00009358166,0.0006986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1439848,"threshold_uncertainty_score":0.8034981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06965433626529506,"score_gpt":0.3886010275041646,"score_spread":0.3189466912388696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}