{"id":"W2558451800","doi":"10.1371/journal.pone.0167235","title":"Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson’s Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Atuka (Canada)","funders":"Krembil Foundation","keywords":"Substantia nigra; Dopaminergic; Parkinson's disease; Neuroscience; Dopamine; Alpha-synuclein; Biology; Medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001565649,0.0008896175,0.0005762285,0.0007874097,0.0006107119,0.001052896,0.0006866045,0.0009514713,0.001837561],"category_scores_gemma":[0.0004942613,0.0003432385,0.0004736233,0.0003325989,0.000695698,0.0006836656,0.0004353992,0.00125266,0.0005425546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007283335,"about_ca_system_score_gemma":0.000971977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002420245,"about_ca_topic_score_gemma":0.004873877,"domain_scores_codex":[0.999392,0.0001819192,0.00004991536,0.0001198737,0.0001920091,0.00006416568],"domain_scores_gemma":[0.9997234,0.00005913636,0.0000812288,0.00002989526,0.00006042609,0.00004584029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001679797,0.000228479,0.0001962607,0.0001128761,0.00001298232,0.0001229371,0.0001403603,0.0003563695,0.9946477,0.0004146071,0.000129994,0.003469513],"study_design_scores_gemma":[0.0001412371,0.006907826,0.003900848,0.0001191885,0.000153559,0.001276925,0.0001810493,0.005062467,0.9658274,0.0008225848,0.01556009,0.00004667768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9083159,0.005941264,0.077631,0.0007419579,0.0001607692,0.001766684,0.0007019442,0.0004363022,0.004304137],"genre_scores_gemma":[0.8386422,0.007382936,0.1388064,0.000401916,0.00007153351,0.001959429,0.0012766,0.0002803282,0.01117872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002420245,"threshold_uncertainty_score":0.008280039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04774732558843117,"score_gpt":0.284248662719965,"score_spread":0.2365013371315338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}