{"id":"W2558507310","doi":"10.1107/s2053273314095564","title":"Allosteric Signaling in Dihydrodipicolinate Synthase","year":2014,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations and Advances","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Allosteric regulation; Lysine; Enzyme; Biochemistry; Allosteric enzyme; Aspartate carbamoyltransferase; Biology; Active site; Chemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002807723,0.0001281415,0.000147463,0.0002648722,0.0002901345,0.0001355821,0.0000753288,0.00006413993,0.0001973379],"category_scores_gemma":[0.00007869273,0.0001152545,0.0000380315,0.0004474719,0.0001276573,0.0007135787,0.00002873313,0.0001114427,0.000001316566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001650241,"about_ca_system_score_gemma":0.00001126899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004593529,"about_ca_topic_score_gemma":0.0004646919,"domain_scores_codex":[0.9990317,0.00008747529,0.0002389519,0.0003205283,0.0001249393,0.0001964469],"domain_scores_gemma":[0.9995318,0.0001114344,0.0001065652,0.00014347,0.00004629493,0.00006045233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002988069,0.00003805486,0.002537203,0.00002747676,0.000004067419,8.880667e-7,0.000116814,0.0003141906,0.9922217,0.000963841,0.00001808164,0.003727792],"study_design_scores_gemma":[0.00245853,0.0008723106,0.03714376,0.0002071281,0.00008974513,0.0001181639,0.001038117,0.004041037,0.01171782,0.04134645,0.8997932,0.001173727],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910695,0.0001608173,0.005922662,0.0002934314,0.0006141502,0.0001334946,0.000004342537,0.00009449653,0.001707109],"genre_scores_gemma":[0.9981694,0.0001827406,0.001237604,0.0001402953,0.0001631479,0.00003505794,0.00001523547,0.00001021768,0.00004633134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9805039,"threshold_uncertainty_score":0.469994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007962755801048322,"score_gpt":0.2399917631503275,"score_spread":0.2320290073492792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}