{"id":"W2558513717","doi":"10.1182/blood.v120.21.1662.1662","title":"Identification of a Unique Autophagy Gene Expression Signature in CD34+ CML Stem/Progenitor Cells That Correlates with Clinical Response to Imatinib Mesylate","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Leukemia & Lymphoma Society of Canada; Genome British Columbia; BC Cancer Agency","funders":"","keywords":"Stem cell; Autophagy; ATG5; Imatinib mesylate; Cancer research; CD34; Progenitor cell; Nilotinib; Dasatinib; Myeloid leukemia; Biology; Tyrosine-kinase inhibitor; Haematopoiesis; Imatinib; Medicine; Tyrosine kinase; Internal medicine; Apoptosis; Cell biology; Cancer; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119741,0.000142058,0.0002315749,0.0006030385,0.0001511813,0.000212982,0.00007922337,0.0002193651,0.001051589],"category_scores_gemma":[0.0002604552,0.000105196,0.00008998241,0.0003096177,0.0001763946,0.00009467607,0.0001391012,0.0001849222,0.000239646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000805686,"about_ca_system_score_gemma":0.0000679087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001935851,"about_ca_topic_score_gemma":0.0002121591,"domain_scores_codex":[0.999933,0.000009519407,0.000008114163,0.00001688824,0.000018131,0.00001436593],"domain_scores_gemma":[0.9998583,0.00003129352,0.000048319,0.00001028479,0.00002250761,0.00002934216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000942108,0.00006441351,0.1164165,0.00005063586,0.00002505811,0.0004632202,0.0001717994,0.0001301985,0.8753484,0.00006602921,0.00009465484,0.006227032],"study_design_scores_gemma":[0.00003803413,0.0008334796,0.9071987,0.000006931017,0.00004751066,0.002594711,0.0002265315,0.000945319,0.08690951,0.00009838038,0.001091475,0.000009335049],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999472,0.0001050155,0.000139394,0.000005731532,0.000001197413,0.000007549803,0.0001176172,0.000004398792,0.0001471415],"genre_scores_gemma":[0.9986026,0.00008047208,0.0005176693,0.00001688939,0.000005913333,0.00003187165,0.0004619217,0.000002476205,0.0002802552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051589,"threshold_uncertainty_score":0.003517866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215117853545327,"score_gpt":0.3017118260677598,"score_spread":0.2802000407132271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}