{"id":"W2558513990","doi":"10.1016/j.molcel.2016.10.033","title":"Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination","year":2016,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Ottawa; Université de Montréal; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Proliferating cell nuclear antigen; Biology; Homologous recombination; DNA repair; DNA clamp; DNA damage; Cell biology; Establishment of sister chromatid cohesion; DNA; Replication protein A; DNA polymerase; Molecular biology; DNA replication; Cohesin; Biochemistry; Chromatin; DNA-binding protein; Gene; Reverse transcriptase; RNA; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003180104,0.0001681511,0.0001670191,0.00001831632,0.00004222008,0.0000104506,0.0001949395,0.0001934001,0.00005986445],"category_scores_gemma":[0.00009205881,0.0001445158,0.0001075866,0.00008438688,0.00004891278,0.00001081316,0.0001173598,0.00005057594,0.00001528848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004556648,"about_ca_system_score_gemma":0.00004442618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001416875,"about_ca_topic_score_gemma":0.000002736201,"domain_scores_codex":[0.9987154,0.0001572385,0.0002697255,0.0004471838,0.0001682128,0.0002422607],"domain_scores_gemma":[0.9991403,0.00001750966,0.0001716251,0.0004946893,0.000127654,0.00004818123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002442205,0.0001222136,0.0002337185,0.00003375861,0.00002081565,0.000002107397,0.00005124393,0.00001367993,0.9985609,0.0001354709,0.0001045818,0.0006970706],"study_design_scores_gemma":[0.0005398904,0.0003594093,0.00008492081,0.000009800588,0.00001646836,0.00000282155,0.00001878109,0.00003010814,0.9950747,0.001228355,0.002447353,0.0001873345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9289513,0.0005783556,0.06826047,0.0001366906,0.0001101724,0.0003269076,0.00003878292,0.00002717283,0.001570113],"genre_scores_gemma":[0.9928672,0.00006944004,0.006363574,0.00004361332,0.00001797425,0.00001165135,0.00009843682,0.0000341639,0.0004939917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06391582,"threshold_uncertainty_score":0.5893182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009166830431272891,"score_gpt":0.214652169441807,"score_spread":0.2054853390105341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}