{"id":"W2558575595","doi":"10.1107/s2053273314092018","title":"The Ryanodine Receptor: Arrhythmias and Muscle Disorders at High Resolution","year":2014,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations and Advances","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor; RYR1; Ryanodine receptor 2; Endoplasmic reticulum; Malignant hyperthermia; Calcium; Cell biology; Calcium signaling; Intracellular; Biology; Cardiac muscle; Extracellular; Second messenger system; Cytosol; Biophysics; Chemistry; Biochemistry; Internal medicine; Endocrinology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004660488,0.0003673844,0.0004910614,0.0008083219,0.0002570047,0.0008111391,0.0005984934,0.001223678,0.004814358],"category_scores_gemma":[0.0009310876,0.0002700609,0.0003020113,0.0006856913,0.0002708892,0.001026305,0.0006745369,0.001137252,0.003721201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758059,"about_ca_system_score_gemma":0.0002463672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007851289,"about_ca_topic_score_gemma":0.0006172321,"domain_scores_codex":[0.9996789,0.00002913379,0.00002240225,0.00006688765,0.0001749163,0.00002777694],"domain_scores_gemma":[0.9997384,0.00004249937,0.0000510607,0.00004485272,0.00008232064,0.00004089854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000469495,0.00008910576,0.01238019,0.001675248,0.0002791994,0.01160364,0.0004019375,0.002457727,0.5570389,0.01034993,0.1026057,0.300649],"study_design_scores_gemma":[0.0001256217,0.0001968544,0.05934245,0.0007154439,0.000403549,0.09105143,0.0004174619,0.01318236,0.09961282,0.0201554,0.7146001,0.0001965417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2460903,0.5044646,0.1420176,0.01791415,0.003680679,0.0001702915,0.006984896,0.006264129,0.0724133],"genre_scores_gemma":[0.7418724,0.1120757,0.08717888,0.004652351,0.002191183,0.0001573931,0.007599616,0.001053007,0.04321956],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004814358,"threshold_uncertainty_score":0.01610565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005271987394609817,"score_gpt":0.2186766121501212,"score_spread":0.2134046247555113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}