{"id":"W2558592416","doi":"10.1093/annonc/mdw392.28","title":"Germline and somatic multi-gene sequencing in patients (pts) with advanced high grade serous ovarian cancer (HGSOC) and triple negative breast cancer (TNBC)","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"PALB2; Germline; Medicine; Olaparib; Germline mutation; Breast cancer; Cancer; Cancer research; Triple-negative breast cancer; Genetic testing; Ovarian cancer; Somatic cell; Oncology; Internal medicine; Gene; Mutation; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009963354,0.0001609693,0.0001820344,0.0004307521,0.0003464945,0.0003928074,0.0001143421,0.0003803482,0.001596422],"category_scores_gemma":[0.0008746369,0.0001540627,0.0001785833,0.0004560107,0.0002166477,0.000246629,0.0002472022,0.0003091528,0.0001478407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001700123,"about_ca_system_score_gemma":0.0002144373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001821936,"about_ca_topic_score_gemma":0.00241339,"domain_scores_codex":[0.9999064,0.00001111207,0.00001153449,0.00002758907,0.00001470197,0.00002859217],"domain_scores_gemma":[0.9997411,0.00007433484,0.00007982115,0.00001153624,0.00001775268,0.00007543447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004586199,0.0000399479,0.9920619,0.000009327306,0.00001586375,0.003131669,0.0001280842,0.00007768268,0.002043858,0.00003252152,0.0001097431,0.001890857],"study_design_scores_gemma":[0.00001470146,0.0002981449,0.9869676,0.000005122339,0.0000345444,0.01118514,0.0003955956,0.00031704,0.0004190689,0.00009474462,0.0002640965,0.000004219867],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996566,0.00003892705,0.00001435697,0.00001598668,0.000002171093,0.000001212475,0.00006876824,0.000001105348,0.0002009709],"genre_scores_gemma":[0.9997509,0.00002855728,0.00002258315,0.00001988912,0.000004338591,0.000001368559,0.00008232395,8.527223e-7,0.00008931784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821936,"threshold_uncertainty_score":0.005340576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02975269438257382,"score_gpt":0.3272143129081854,"score_spread":0.2974616185256116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}