{"id":"W2558608270","doi":"10.1074/jbc.m116.764720","title":"Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Biomedical Imaging and Bioengineering; National Eye Institute; Canadian Institutes of Health Research; Cystic Fibrosis Foundation Therapeutics; National Cancer Institute; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Potentiator; Cystic fibrosis; Ivacaftor; Regulator; Cystic fibrosis transmembrane conductance regulator; Translation (biology); Function (biology); Ambroxol; Medicine; Chemistry; Biology; Cell biology; Biochemistry; Anatomy; Pharmacology; Internal medicine; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002523828,0.0003935653,0.0004527558,0.0002025502,0.0001970786,0.0003222484,0.0002541322,0.0004354792,0.002987622],"category_scores_gemma":[0.0003684757,0.0001715274,0.0003437908,0.0001478562,0.0003348336,0.0001869126,0.0003470469,0.000696678,0.0008853923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001458221,"about_ca_system_score_gemma":0.0002295314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000417618,"about_ca_topic_score_gemma":0.0007152042,"domain_scores_codex":[0.9996958,0.00005573427,0.00005794773,0.00005546279,0.00009647861,0.0000386172],"domain_scores_gemma":[0.9997459,0.00006859857,0.00005714585,0.00005496575,0.0000237648,0.00004975336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001156704,0.00002371992,0.0001767149,0.00002112345,0.000005652499,0.0000903792,0.00001733727,0.00003764387,0.9984851,0.00004312278,0.0000403921,0.0009430873],"study_design_scores_gemma":[0.00003720942,0.000797004,0.002714375,0.000005458496,0.00002947451,0.0006561972,0.00005058252,0.000342171,0.9924663,0.00002775047,0.002866999,0.000006462052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995901,0.0003671215,0.001503898,0.000102854,0.00006026743,0.00007370141,0.0005301479,0.00008716998,0.001373689],"genre_scores_gemma":[0.9911753,0.0004924822,0.003109869,0.00007965721,0.00002405163,0.00009834926,0.0007800577,0.00008059049,0.004159498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002987622,"threshold_uncertainty_score":0.009994566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879300737204966,"score_gpt":0.2574027801468105,"score_spread":0.2386097727747609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}