{"id":"W2558695084","doi":"10.1182/blood.v124.21.4037.4037","title":"Exogenous Apo-Transferrin Increases Monoferric Transferrin, Decreasing Cytosolic Iron Uptake and Heme and Globin Synthesis in β-Thalassemic Mice","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Ineffective erythropoiesis; Erythropoiesis; Chemistry; Transferrin saturation; Thalassemia; Anemia; Hemoglobin; Transferrin; Internal medicine; Biochemistry; Endocrinology; Iron deficiency; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335189,0.0005566921,0.0003504799,0.0007456843,0.0001601393,0.0004046699,0.0003422318,0.0006532481,0.002079768],"category_scores_gemma":[0.0001603414,0.000281883,0.0003441469,0.0002269616,0.0003823783,0.0002458505,0.0001997716,0.001055446,0.0004901628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003707858,"about_ca_system_score_gemma":0.0002097345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079058,"about_ca_topic_score_gemma":0.0009260654,"domain_scores_codex":[0.9997205,0.00004825377,0.00003735194,0.00007548084,0.0000648349,0.00005362739],"domain_scores_gemma":[0.9995602,0.00004259997,0.0001472387,0.00003241558,0.00003495633,0.0001825801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000361349,0.00008950883,0.00024685,0.00003574518,0.000009507329,0.00006274622,0.00002880984,0.00004202029,0.9979103,0.00007981165,0.00008363016,0.001049666],"study_design_scores_gemma":[0.0001406615,0.001185681,0.008741785,0.00002474985,0.00006185142,0.0005899194,0.00008283859,0.00124843,0.9836766,0.0001083673,0.004123388,0.00001571917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898703,0.001743204,0.003686961,0.0004428806,0.00007245525,0.00006606791,0.001827282,0.0004980378,0.001792956],"genre_scores_gemma":[0.986704,0.001091566,0.003814481,0.0002994817,0.00003261577,0.0001376844,0.001087559,0.0001699341,0.006662855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002079768,"threshold_uncertainty_score":0.006957471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007581716716182674,"score_gpt":0.2123911351307201,"score_spread":0.2048094184145374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}